Abstract
The mitotic kinase cdc2 must bind to a regulatory subunit - a cyclin - to be active. Cyclin binding controls the timing of activation of the kinase subunit, by modulating its interaction with upstream regulatory enzymes, and it also determines subcellular localization and substrate specificity. In this article, I summarize our present knowledge of the mechanisms that control cdc2 activation.
Original language | English (US) |
---|---|
Pages (from-to) | 287-289 |
Number of pages | 3 |
Journal | Trends in Cell Biology |
Volume | 3 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology