Abstract
The p16INK4 (MTS1) gene has many features of a tumor suppressor gene. It maps to 9p21, a region of frequent loss of heterozygosity in a variety of tumor types. It encodes an inhibitor of cyclin-dependent kinase 4, and its homozygous deletion is common in tumor-derived cell lines. To examine its tumor suppressive function and its potential in cancer gene replacement therapy, wild-type P16INK4 was expressed in an adenovirus-derived gene delivery system and introduced into lung cancer cell lines that do not express pl6INK\ Expression of the introduced p16INK4 blocked tumor cell entry into S phase of the cell cycle and inhibited tumor proliferation both in vitro and in vivo. These observations strongly support that p26INK4 is a tumor suppressor gene and is a candidate for cancer gene replacement therapy.
Original language | English (US) |
---|---|
Pages (from-to) | 3250-3253 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 55 |
Issue number | 15 |
State | Published - Aug 1 1995 |
ASJC Scopus subject areas
- Oncology
- Cancer Research