Cell Cycle-specific Oncogenic Transformation of C3H/10T1/2 Clone 8 Mouse Embryo Cells by 1-β-D-Arabinofuranosylcytosine

John S. Bertram; Mary S. Baker; William F. Benedict

Cell Cycle-specific Oncogenic Transformation of C3H/10T¹/2 Clone 8 Mouse Embryo Cells by 1-β-D-Arabinofuranosylcytosine

John S. Bertram, Mary S. Baker, William F. Benedict

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

1-0-D-Arabinofuranosylcytosine at concentrations ranging from 10^-3to 10^-6M induces oncogenic transformation in the C3H/10TV2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G₁phase of the cell cycle.

Original language	English (US)
Pages (from-to)	2214-2217
Number of pages	4
Journal	Cancer Research
Volume	37
State	Published - Jul 1977

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Cell Cycle-specific Oncogenic Transformation of C3H/10T1/2 Clone 8 Mouse Embryo Cells by 1-β-D-Arabinofuranosylcytosine",

abstract = "1-0-D-Arabinofuranosylcytosine at concentrations ranging from 10-3to 10-6M induces oncogenic transformation in the C3H/10TV2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1phase of the cell cycle.",

author = "Bertram, {John S.} and Baker, {Mary S.} and Benedict, {William F.}",

year = "1977",

month = jul,

language = "English (US)",

volume = "37",

pages = "2214--2217",

journal = "Cancer Research",

issn = "0008-5472",

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T1 - Cell Cycle-specific Oncogenic Transformation of C3H/10T1/2 Clone 8 Mouse Embryo Cells by 1-β-D-Arabinofuranosylcytosine

AU - Bertram, John S.

AU - Baker, Mary S.

AU - Benedict, William F.

PY - 1977/7

Y1 - 1977/7

N2 - 1-0-D-Arabinofuranosylcytosine at concentrations ranging from 10-3to 10-6M induces oncogenic transformation in the C3H/10TV2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1phase of the cell cycle.

AB - 1-0-D-Arabinofuranosylcytosine at concentrations ranging from 10-3to 10-6M induces oncogenic transformation in the C3H/10TV2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1phase of the cell cycle.

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M3 - Article

AN - SCOPUS:84965818480

SN - 0008-5472

VL - 37

SP - 2214

EP - 2217

JO - Cancer Research

JF - Cancer Research

ER -

Cell Cycle-specific Oncogenic Transformation of C3H/10T¹/2 Clone 8 Mouse Embryo Cells by 1-β-D-Arabinofuranosylcytosine

Abstract

ASJC Scopus subject areas

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