Cell cycle specific oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by 1 β D arabinofuranosylcytosine

P. A. Jones; M. S. Baker; J. S. Bertram; W. F. Benedict

Cell cycle specific oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by 1 β D arabinofuranosylcytosine

P. A. Jones, M. S. Baker, J. S. Bertram, W. F. Benedict

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

1-β-D-Arabinofuranosylcytosine at concentrations ranging from 10^-3 to 10^-6 M induces oncogenic transformation in the C3H/10T1/2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G₁ phase of the cell cycle.

Original language	English (US)
Pages (from-to)	I
Journal	Cancer Research
Volume	37
Issue number	7
State	Published - 1977

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Cell cycle specific oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by 1 β D arabinofuranosylcytosine",

abstract = "1-β-D-Arabinofuranosylcytosine at concentrations ranging from 10-3 to 10-6 M induces oncogenic transformation in the C3H/10T1/2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1 phase of the cell cycle.",

author = "Jones, {P. A.} and Baker, {M. S.} and Bertram, {J. S.} and Benedict, {W. F.}",

year = "1977",

language = "English (US)",

volume = "37",

pages = "I",

journal = "Cancer Research",

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T1 - Cell cycle specific oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by 1 β D arabinofuranosylcytosine

AU - Jones, P. A.

AU - Baker, M. S.

AU - Bertram, J. S.

AU - Benedict, W. F.

PY - 1977

Y1 - 1977

N2 - 1-β-D-Arabinofuranosylcytosine at concentrations ranging from 10-3 to 10-6 M induces oncogenic transformation in the C3H/10T1/2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1 phase of the cell cycle.

AB - 1-β-D-Arabinofuranosylcytosine at concentrations ranging from 10-3 to 10-6 M induces oncogenic transformation in the C3H/10T1/2 clone 8 mouse embryo cell line. Cell lines derived from type III transformed foci grew in soft agarose and produced tumors in immunosuppressed syngeneic mice. With cells synchronized by postconfluent inhibition of growth or isoleucine deprivation, transformation was cell cycle dependent. Maximal transformation was seen in cells treated when in S phase, although some transformation was seen in cells treated in G1 phase of the cell cycle.

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C2 - 861946

AN - SCOPUS:0017684177

SN - 0008-5472

VL - 37

SP - I

JO - Cancer Research

JF - Cancer Research

IS - 7

ER -

Cell cycle specific oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by 1 β D arabinofuranosylcytosine

Abstract

ASJC Scopus subject areas

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