@article{901271ed4e534c3dafef3b7753697db2,
title = "Cell-to-cell miRNA transfer: From body homeostasis to therapy",
abstract = "The role of non-protein coding RNAs (ncRNAs), microRNAs (miRNAs) in particular, as fine-tuners of both pathological and physiological processes is no longer a matter of debate. With the recent discovery of miRNAs in a wide variety of body fluids and considering them as tools employed in horizontal gene transfer between cells, a new horizon opens in the field of diagnosis and therapeutics. Circulating miRNAs not only enable the communication among cells, but also provide insight into the pathological and physiological state of the originating cells. In this review we summarize the recent advances made in this field, arguing for compelling translation of miRNAs into clinical practice. Moreover, we provide overview of their characteristics and how they impact the evolution of tumor microenvironment and cell-to-cell communication, advancing the idea that miRNAs may function as hormones.",
keywords = "Body fluids, HGT, Hormones, Nanovesicles, Therapy, miRNAs",
author = "Redis, {Roxana S.} and Steliana Calin and Yaling Yang and You, {M. James} and Calin, {George A.}",
note = "Funding Information: Dr. Calin is The Alan M. Gewirtz Leukemia & Lymphoma Society Scholar. He is supported also as a Fellow at The University of Texas MD Anderson Research Trust , as a University of Texas System Regents Research Scholar and by the CLL Global Research Foundation . Work in Dr. Calin's laboratory is supported in part by the NIH/NCI , a Department of Defense Breast Cancer Idea Award , Developmental Research Awards in Breast Cancer, Ovarian Cancer, Brain Cancer, Prostate, Multiple Myeloma and Leukemia SPOREs , the Laura and John Arnold Foundation , the RGK Foundation and the Estate of C. G. Johnson, Jr. . We thank Donald Norwood, ELS, Department of Scientific Publications, The University of Texas MD Anderson Cancer Center, for expert editorial assistance. Funding Information: Work in Dr. MJ You's laboratory is supported in part by NIH/NCI R01 CA164346, Ladies Leukemia League , American Cancer Society IRG , Developmental Research Awards in Leukemia SPORE CA100632, and Center for Inflammation and Cancer , IRG and Physician Scientist Award of UT MD Anderson Cancer Center .",
year = "2012",
month = nov,
doi = "10.1016/j.pharmthera.2012.08.003",
language = "English (US)",
volume = "136",
pages = "169--174",
journal = "Pharmacology and Therapeutics",
issn = "0163-7258",
number = "2",
}