@inproceedings{b9d6b42a71064d0e836f6e868e4dd62c,
title = "CellMiner: A database tool for the NCI-60 cancer cell lines",
abstract = "CellMiner is a web-accessible relational database tool that organizes, navigates, and integrates multiple types of molecular profile data on the NCI-60 cell line panel at the t DNA, RNA, protein, and small-molecule levels. The database was developed using high throughput molecular profile t expression arrays on the NCI-60 cancer cell lines generated by our lab and collaborators. Annotations for each project t and associated metadata at the sample and platform level are stored in a MySQL relational database and are linked to array hybridization data. Data can be queried and downloaded through a web browser. A Data Intersection tool i that selects data for those genes that are common between s two or more datasets simplifies integromic analysis of multiple platforms. Each dataset download includes a file r describing the experimental and analytic methods for the s dataset in publication-level detail. In addition to its role as an integrative resource for the NCI-60, the CellMiner package also serves as a shell for incorporation of molecular profile data on other cell types. Currently included are multiple molecular data sets on DU145 prostate cancer cell line and t RC0.1, a topoisomerase 1-resistant derivative of DU145 cell line. CellMiner provides biologists and biomedical scientists with a flexible, focused database tool for access to diverse i molecular profile information and detailed annotations.",
keywords = "Cancer cell lines, Data integration, Database, NCI-60, Web application",
author = "Shankavaram, {Uma T.} and Sudhir Varma and David Kane and Margot Sunshine and Krishna Chary and Reinhold, {William C.} and Weinstein, {John N.}",
year = "2008",
language = "English (US)",
isbn = "1601320558",
series = "Proceedings of the 2008 International Conference on Bioinformatics and Computational Biology, BIOCOMP 2008",
pages = "315--323",
booktitle = "Proceedings of the 2008 International Conference on Bioinformatics and Computational Biology, BIOCOMP 2008",
note = "2008 International Conference on Bioinformatics and Computational Biology, BIOCOMP 2008 ; Conference date: 14-07-2008 Through 17-07-2008",
}