TY - JOUR
T1 - Cellular and molecular biology of biliary tract cancers
AU - Rashid, Asif
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/10
Y1 - 2002/10
N2 - Cancer of the biliary tract has been associated with point mutations of K-ras and β-catenin proto-oncogenes; alterations of p53, p16, APC, and DPC4 tumor suppressor genes by a combination of chromosomal deletion, mutation, or methylation; and infrequently microsatellite instability. The frequencies of these alterations vary by location and race of the patient, tumor subsite, histology, and associated disease. Advances in the understanding of the genetics of this disease will help in diagnosing biliary tract cancer, screening at-risk patients, and developing therapies.
AB - Cancer of the biliary tract has been associated with point mutations of K-ras and β-catenin proto-oncogenes; alterations of p53, p16, APC, and DPC4 tumor suppressor genes by a combination of chromosomal deletion, mutation, or methylation; and infrequently microsatellite instability. The frequencies of these alterations vary by location and race of the patient, tumor subsite, histology, and associated disease. Advances in the understanding of the genetics of this disease will help in diagnosing biliary tract cancer, screening at-risk patients, and developing therapies.
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U2 - 10.1016/S1055-3207(02)00042-X
DO - 10.1016/S1055-3207(02)00042-X
M3 - Review article
C2 - 12607585
AN - SCOPUS:0036812996
SN - 1055-3207
VL - 11
SP - 995
EP - 1009
JO - Surgical oncology clinics of North America
JF - Surgical oncology clinics of North America
IS - 4
ER -