TY - JOUR
T1 - Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
AU - Zeisberg, Michael
AU - Kalluri, Raghu
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Fibrosis is a pathological scarring process that leads to destruction of organ architecture and impairment of organ function. Chronic loss of organ function in most organs, including bone marrow, heart, intestine, kidney, liver, lung, and skin, is associated with fibrosis, contributing to an estimated one third of natural deaths worldwide. Effective therapies to prevent or to even reverse existing fibrotic lesions are not yet available in any organ. There is hope that an understanding of common fibrosis pathways will lead to development of antifibrotic therapies that are effective in all of these tissues in the future. Here we review common and organ-specific pathways of tissue fibrosis.
AB - Fibrosis is a pathological scarring process that leads to destruction of organ architecture and impairment of organ function. Chronic loss of organ function in most organs, including bone marrow, heart, intestine, kidney, liver, lung, and skin, is associated with fibrosis, contributing to an estimated one third of natural deaths worldwide. Effective therapies to prevent or to even reverse existing fibrotic lesions are not yet available in any organ. There is hope that an understanding of common fibrosis pathways will lead to development of antifibrotic therapies that are effective in all of these tissues in the future. Here we review common and organ-specific pathways of tissue fibrosis.
KW - Epigenetics
KW - Fibroblasts
KW - Fibrosis
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=84873344021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873344021&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00328.2012
DO - 10.1152/ajpcell.00328.2012
M3 - Article
C2 - 23255577
AN - SCOPUS:84873344021
SN - 0363-6143
VL - 304
SP - C216-C225
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
IS - 3
ER -