Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

A. Cousins; O. Olivares; E. Markert; A. Manoharan; X. Bubnova; S. Bresolin; M. Degn; Z. Li; D. Silvestri; G. McGregor; S. Tumanov; D. Sumpton; J. J. Kamphorst; A. M. Michie; P. Herzyk; M. G. Valsecchi; A. E. Yeoh; K. Schmiegelow; G. te Kronnie; E. Gottlieb; C. Halsey

doi:10.1038/s41375-022-01722-x

Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

A. Cousins, O. Olivares, E. Markert, A. Manoharan, X. Bubnova, S. Bresolin, M. Degn, Z. Li, D. Silvestri, G. McGregor, S. Tumanov, D. Sumpton, J. J. Kamphorst, A. M. Michie, P. Herzyk, M. G. Valsecchi, A. E. Yeoh, K. Schmiegelow, G. te Kronnie, E. GottliebC. Halsey

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Original language	English (US)
Pages (from-to)	2903-2907
Number of pages	5
Journal	Leukemia
Volume	36
Issue number	12
DOIs	https://doi.org/10.1038/s41375-022-01722-x
State	Published - Dec 2022
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/s41375-022-01722-x

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Cousins, A., Olivares, O., Markert, E., Manoharan, A., Bubnova, X., Bresolin, S., Degn, M., Li, Z., Silvestri, D., McGregor, G., Tumanov, S., Sumpton, D., Kamphorst, J. J., Michie, A. M., Herzyk, P., Valsecchi, M. G., Yeoh, A. E., Schmiegelow, K., te Kronnie, G., ... Halsey, C. (2022). Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36(12), 2903-2907. https://doi.org/10.1038/s41375-022-01722-x

Cousins, A, Olivares, O, Markert, E, Manoharan, A, Bubnova, X, Bresolin, S, Degn, M, Li, Z, Silvestri, D, McGregor, G, Tumanov, S, Sumpton, D, Kamphorst, JJ, Michie, AM, Herzyk, P, Valsecchi, MG, Yeoh, AE, Schmiegelow, K, te Kronnie, G, Gottlieb, E & Halsey, C 2022, 'Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways', Leukemia, vol. 36, no. 12, pp. 2903-2907. https://doi.org/10.1038/s41375-022-01722-x

@article{9181a6e743e7403e99e0bd981e1bc340,

title = "Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways",

author = "A. Cousins and O. Olivares and E. Markert and A. Manoharan and X. Bubnova and S. Bresolin and M. Degn and Z. Li and D. Silvestri and G. McGregor and S. Tumanov and D. Sumpton and Kamphorst, {J. J.} and Michie, {A. M.} and P. Herzyk and Valsecchi, {M. G.} and Yeoh, {A. E.} and K. Schmiegelow and {te Kronnie}, G. and E. Gottlieb and C. Halsey",

note = "Funding Information: We would like to thank the patients and families who contributed samples to the genomic databases used in this study. In addition, we thank J. Goodfellow, H. Willison, S. Bhatti, and YY for assistance with obtaining primary CSF samples, the NHS Greater Glasgow and Clyde Biorepository for control plasma, and C. Orange and L. Stevenson for help with histology. Histology slides were scanned by the University of Glasgow slide scanning and image analysis service at the Queen Elizabeth University Hospital. RNA-seq was performed by the Glasgow Polyomics research facility at the University of Glasgow. LC-MS metabolomic analysis was carried out by G MacKay, D Sumpton, and N van der Broek in the Metabolomics unit in the Beatson Institute, Glasgow. We also thank K. Keeshan and the Biological Services Unit, Cancer Research UK Beatson Institute of Cancer Research for animal assistance. The computational work for this article was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg). This work is part of the Danish nation-wide research program Childhood Oncology Network Targeting Research, Organisation & Life expectancy (CONTROL) and supported by the Danish Cancer Society (R-257-A14720) and the Danish Childhood Cancer Foundation (2019-5934 and 2020-5769). This work was supported by the Chief Scientist Office (OO, PH, EG and CH, grant ETM/374) the Fondazione Cariparo, CRUK core funding to the CRUK Beatson Institute (A17196 and A31287), CRUK Glasgow Centre (A18076 and A25142), CRUK Career Development Fellowship (A17728) (JK), Rosetrees Trust studentship (M480) (GMcG), CRUK core funding (A18278) (EG), and the William and Elizabeth Davies Foundation (AC, Clinical Research Fellowship). Funding Information: We would like to thank the patients and families who contributed samples to the genomic databases used in this study. In addition, we thank J. Goodfellow, H. Willison, S. Bhatti, and YY for assistance with obtaining primary CSF samples, the NHS Greater Glasgow and Clyde Biorepository for control plasma, and C. Orange and L. Stevenson for help with histology. Histology slides were scanned by the University of Glasgow slide scanning and image analysis service at the Queen Elizabeth University Hospital. RNA-seq was performed by the Glasgow Polyomics research facility at the University of Glasgow. LC-MS metabolomic analysis was carried out by G MacKay, D Sumpton, and N van der Broek in the Metabolomics unit in the Beatson Institute, Glasgow. We also thank K. Keeshan and the Biological Services Unit, Cancer Research UK Beatson Institute of Cancer Research for animal assistance. The computational work for this article was partially performed on resources of the National Supercomputing Centre, Singapore ( https://www.nscc.sg ). This work is part of the Danish nation-wide research program Childhood Oncology Network Targeting Research, Organisation & Life expectancy (CONTROL) and supported by the Danish Cancer Society (R-257-A14720) and the Danish Childhood Cancer Foundation (2019-5934 and 2020-5769). This work was supported by the Chief Scientist Office (OO, PH, EG and CH, grant ETM/374) the Fondazione Cariparo, CRUK core funding to the CRUK Beatson Institute (A17196 and A31287), CRUK Glasgow Centre (A18076 and A25142), CRUK Career Development Fellowship (A17728) (JK), Rosetrees Trust studentship (M480) (GMcG), CRUK core funding (A18278) (EG), and the William and Elizabeth Davies Foundation (AC, Clinical Research Fellowship). ",

year = "2022",

month = dec,

doi = "10.1038/s41375-022-01722-x",

language = "English (US)",

volume = "36",

pages = "2903--2907",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "12",

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TY - JOUR

T1 - Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

AU - Cousins, A.

AU - Olivares, O.

AU - Markert, E.

AU - Manoharan, A.

AU - Bubnova, X.

AU - Bresolin, S.

AU - Degn, M.

AU - Li, Z.

AU - Silvestri, D.

AU - McGregor, G.

AU - Tumanov, S.

AU - Sumpton, D.

AU - Kamphorst, J. J.

AU - Michie, A. M.

AU - Herzyk, P.

AU - Valsecchi, M. G.

AU - Yeoh, A. E.

AU - Schmiegelow, K.

AU - te Kronnie, G.

AU - Gottlieb, E.

AU - Halsey, C.

N1 - Funding Information: We would like to thank the patients and families who contributed samples to the genomic databases used in this study. In addition, we thank J. Goodfellow, H. Willison, S. Bhatti, and YY for assistance with obtaining primary CSF samples, the NHS Greater Glasgow and Clyde Biorepository for control plasma, and C. Orange and L. Stevenson for help with histology. Histology slides were scanned by the University of Glasgow slide scanning and image analysis service at the Queen Elizabeth University Hospital. RNA-seq was performed by the Glasgow Polyomics research facility at the University of Glasgow. LC-MS metabolomic analysis was carried out by G MacKay, D Sumpton, and N van der Broek in the Metabolomics unit in the Beatson Institute, Glasgow. We also thank K. Keeshan and the Biological Services Unit, Cancer Research UK Beatson Institute of Cancer Research for animal assistance. The computational work for this article was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg). This work is part of the Danish nation-wide research program Childhood Oncology Network Targeting Research, Organisation & Life expectancy (CONTROL) and supported by the Danish Cancer Society (R-257-A14720) and the Danish Childhood Cancer Foundation (2019-5934 and 2020-5769). This work was supported by the Chief Scientist Office (OO, PH, EG and CH, grant ETM/374) the Fondazione Cariparo, CRUK core funding to the CRUK Beatson Institute (A17196 and A31287), CRUK Glasgow Centre (A18076 and A25142), CRUK Career Development Fellowship (A17728) (JK), Rosetrees Trust studentship (M480) (GMcG), CRUK core funding (A18278) (EG), and the William and Elizabeth Davies Foundation (AC, Clinical Research Fellowship). Funding Information: We would like to thank the patients and families who contributed samples to the genomic databases used in this study. In addition, we thank J. Goodfellow, H. Willison, S. Bhatti, and YY for assistance with obtaining primary CSF samples, the NHS Greater Glasgow and Clyde Biorepository for control plasma, and C. Orange and L. Stevenson for help with histology. Histology slides were scanned by the University of Glasgow slide scanning and image analysis service at the Queen Elizabeth University Hospital. RNA-seq was performed by the Glasgow Polyomics research facility at the University of Glasgow. LC-MS metabolomic analysis was carried out by G MacKay, D Sumpton, and N van der Broek in the Metabolomics unit in the Beatson Institute, Glasgow. We also thank K. Keeshan and the Biological Services Unit, Cancer Research UK Beatson Institute of Cancer Research for animal assistance. The computational work for this article was partially performed on resources of the National Supercomputing Centre, Singapore ( https://www.nscc.sg ). This work is part of the Danish nation-wide research program Childhood Oncology Network Targeting Research, Organisation & Life expectancy (CONTROL) and supported by the Danish Cancer Society (R-257-A14720) and the Danish Childhood Cancer Foundation (2019-5934 and 2020-5769). This work was supported by the Chief Scientist Office (OO, PH, EG and CH, grant ETM/374) the Fondazione Cariparo, CRUK core funding to the CRUK Beatson Institute (A17196 and A31287), CRUK Glasgow Centre (A18076 and A25142), CRUK Career Development Fellowship (A17728) (JK), Rosetrees Trust studentship (M480) (GMcG), CRUK core funding (A18278) (EG), and the William and Elizabeth Davies Foundation (AC, Clinical Research Fellowship).

PY - 2022/12

Y1 - 2022/12

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U2 - 10.1038/s41375-022-01722-x

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SN - 0887-6924

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JO - Leukemia

JF - Leukemia

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ER -

Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

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