Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Henrik Hellquist; Alena Skálová; Leon Barnes; Antonio Cardesa; Lester D.R. Thompson; Asterios Triantafyllou; Michelle D. Williams; Kenneth O. Devaney; Douglas R. Gnepp; Justin A. Bishop; Bruce M. Wenig; Carlos Suárez; Juan P. Rodrigo; Andrés Coca-Pelaz; Primož Strojan; Jatin P. Shah; Marc Hamoir; Patrick J. Bradley; Carl E. Silver; Pieter J. Slootweg; Vincent Vander Poorten; Afshin Teymoortash; Jesus E. Medina; K. Thomas Robbins; Karen T. Pitman; Luiz P. Kowalski; Remco de Bree; William M. Mendenhall; Jean Anderson Eloy; Robert P. Takes; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s12325-016-0298-5

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D.R. Thompson, Asterios Triantafyllou, Michelle D. Williams, Kenneth O. Devaney, Douglas R. Gnepp, Justin A. Bishop, Bruce M. Wenig, Carlos Suárez, Juan P. Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P. Shah, Marc Hamoir, Patrick J. Bradley, Carl E. Silver, Pieter J. SlootwegVincent Vander Poorten, Afshin Teymoortash, Jesus E. Medina, K. Thomas Robbins, Karen T. Pitman, Luiz P. Kowalski, Remco de Bree, William M. Mendenhall, Jean Anderson Eloy, Robert P. Takes, Alessandra Rinaldo, Alfio Ferlito

Pathology

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

Original language	English (US)
Pages (from-to)	357-368
Number of pages	12
Journal	Advances in Therapy
Volume	33
Issue number	3
DOIs	https://doi.org/10.1007/s12325-016-0298-5
State	Published - Mar 1 2016

Keywords

Adenoid cystic carcinoma
Dedifferentiation
Fatal outcome
High-grade transformation
Local recurrence
Lymphatic metastasis
Neck dissection
Neoplasm recurrence
Salivary glands

ASJC Scopus subject areas

Pharmacology (medical)

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10.1007/s12325-016-0298-5

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Hellquist, H., Skálová, A., Barnes, L., Cardesa, A., Thompson, L. D. R., Triantafyllou, A., Williams, M. D., Devaney, K. O., Gnepp, D. R., Bishop, J. A., Wenig, B. M., Suárez, C., Rodrigo, J. P., Coca-Pelaz, A., Strojan, P., Shah, J. P., Hamoir, M., Bradley, P. J., Silver, C. E., ... Ferlito, A. (2016). Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review. Advances in Therapy, 33(3), 357-368. https://doi.org/10.1007/s12325-016-0298-5

Hellquist, H, Skálová, A, Barnes, L, Cardesa, A, Thompson, LDR, Triantafyllou, A, Williams, MD, Devaney, KO, Gnepp, DR, Bishop, JA, Wenig, BM, Suárez, C, Rodrigo, JP, Coca-Pelaz, A, Strojan, P, Shah, JP, Hamoir, M, Bradley, PJ, Silver, CE, Slootweg, PJ, Vander Poorten, V, Teymoortash, A, Medina, JE, Robbins, KT, Pitman, KT, Kowalski, LP, de Bree, R, Mendenhall, WM, Eloy, JA, Takes, RP, Rinaldo, A & Ferlito, A 2016, 'Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review', Advances in Therapy, vol. 33, no. 3, pp. 357-368. https://doi.org/10.1007/s12325-016-0298-5

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title = "Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review",

abstract = "Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.",

keywords = "Adenoid cystic carcinoma, Dedifferentiation, Fatal outcome, High-grade transformation, Local recurrence, Lymphatic metastasis, Neck dissection, Neoplasm recurrence, Salivary glands",

author = "Henrik Hellquist and Alena Sk{\'a}lov{\'a} and Leon Barnes and Antonio Cardesa and Thompson, {Lester D.R.} and Asterios Triantafyllou and Williams, {Michelle D.} and Devaney, {Kenneth O.} and Gnepp, {Douglas R.} and Bishop, {Justin A.} and Wenig, {Bruce M.} and Carlos Su{\'a}rez and Rodrigo, {Juan P.} and Andr{\'e}s Coca-Pelaz and Primo{\v z} Strojan and Shah, {Jatin P.} and Marc Hamoir and Bradley, {Patrick J.} and Silver, {Carl E.} and Slootweg, {Pieter J.} and {Vander Poorten}, Vincent and Afshin Teymoortash and Medina, {Jesus E.} and Robbins, {K. Thomas} and Pitman, {Karen T.} and Kowalski, {Luiz P.} and {de Bree}, Remco and Mendenhall, {William M.} and Eloy, {Jean Anderson} and Takes, {Robert P.} and Alessandra Rinaldo and Alfio Ferlito",

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doi = "10.1007/s12325-016-0298-5",

language = "English (US)",

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T1 - Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma

T2 - A Collective International Review

AU - Hellquist, Henrik

AU - Skálová, Alena

AU - Barnes, Leon

AU - Cardesa, Antonio

AU - Thompson, Lester D.R.

AU - Triantafyllou, Asterios

AU - Williams, Michelle D.

AU - Devaney, Kenneth O.

AU - Gnepp, Douglas R.

AU - Bishop, Justin A.

AU - Wenig, Bruce M.

AU - Suárez, Carlos

AU - Rodrigo, Juan P.

AU - Coca-Pelaz, Andrés

AU - Strojan, Primož

AU - Shah, Jatin P.

AU - Hamoir, Marc

AU - Bradley, Patrick J.

AU - Silver, Carl E.

AU - Slootweg, Pieter J.

AU - Vander Poorten, Vincent

AU - Teymoortash, Afshin

AU - Medina, Jesus E.

AU - Robbins, K. Thomas

AU - Pitman, Karen T.

AU - Kowalski, Luiz P.

AU - de Bree, Remco

AU - Mendenhall, William M.

AU - Eloy, Jean Anderson

AU - Takes, Robert P.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

AB - Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

KW - Adenoid cystic carcinoma

KW - Dedifferentiation

KW - Fatal outcome

KW - High-grade transformation

KW - Local recurrence

KW - Lymphatic metastasis

KW - Neck dissection

KW - Neoplasm recurrence

KW - Salivary glands

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U2 - 10.1007/s12325-016-0298-5

DO - 10.1007/s12325-016-0298-5

M3 - Review article

C2 - 26895332

AN - SCOPUS:84958755163

SN - 0741-238X

VL - 33

SP - 357

EP - 368

JO - Advances in Therapy

JF - Advances in Therapy

IS - 3

ER -

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Abstract

Keywords

ASJC Scopus subject areas

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