TY - JOUR
T1 - Characteristics of lipid-based formulations that influence their biological behavior in the plasma of patients
AU - Wasan, Kishor M.
AU - Lopez-Berestein, Gabriel
PY - 1996
Y1 - 1996
N2 - Patients with cancer and infectious diseases often have changes in the composition and concentration of their different blood components. These changes include variations in the composition and concentration of plasma lipoprotein lipids, in transfer rates of endogenous lipid between different lipoprotein classes, and in concentrations of phagocytic cells (i.e., monocytes and macrophages). It appears that the interaction of many lipid- based drug formulations with plasma lipoproteins and blood phagocytic cells may be responsible for the unpredictable pharmacokinetics and pharmacodynamics of these compounds when administered to patients with diseases. This review examines the potential mechanisms that may explain the biological behavior of lipid-based drug formulations used in the treatment of infectious diseases and cancer.
AB - Patients with cancer and infectious diseases often have changes in the composition and concentration of their different blood components. These changes include variations in the composition and concentration of plasma lipoprotein lipids, in transfer rates of endogenous lipid between different lipoprotein classes, and in concentrations of phagocytic cells (i.e., monocytes and macrophages). It appears that the interaction of many lipid- based drug formulations with plasma lipoproteins and blood phagocytic cells may be responsible for the unpredictable pharmacokinetics and pharmacodynamics of these compounds when administered to patients with diseases. This review examines the potential mechanisms that may explain the biological behavior of lipid-based drug formulations used in the treatment of infectious diseases and cancer.
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U2 - 10.1093/clinids/23.5.1126
DO - 10.1093/clinids/23.5.1126
M3 - Review article
C2 - 8922813
AN - SCOPUS:0029911039
SN - 1058-4838
VL - 23
SP - 1126
EP - 1138
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -