Abstract
Suppression of an antigen‐specific plaque‐forming cell response of human blood lymphocytes can be effected by Tμ+ cells that have been primed previously by antigen in vitro for 6 days. While lacking the capacity to suppress the plaque‐forming response directly, these primed Tμ+ suppressor‐inducer cells stimulate a subpopulation of unprimed Toy− cells to differentiate to Tγ+ suppressor‐effector cells. The Tμ+, Tγ+ and Tμγ− subsets have been shown to be heterogeneous populations of cells. Therefore, the functionally defined T suppressor‐inducer, ‐precursor and ‐effector cells were characterized by OKT monoclonal antibodies and by the capacity to form rosettes with autologous erythrocytes (ar+). Evidence will be presented that in vitro a T4+μ+ar− cell induces a T8+μγ− ar+ precursor cell to differentiate to a T8+γ+ar− suppressor‐effector cell. A similar T suppressor‐effector cell can also be isolated directly from peripheral blood of normal donors.
Original language | English (US) |
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Pages (from-to) | 860-866 |
Number of pages | 7 |
Journal | European Journal of Immunology |
Volume | 12 |
Issue number | 10 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology