TY - JOUR
T1 - Characterizing morphologic subtypes of high-grade serous ovarian cancer by CT
T2 - A retrospective cohort study
AU - Foster, Katherine I.
AU - Handley, Katelyn F.
AU - Glassman, Deanna
AU - Sims, Travis T.
AU - Javadi, Sanaz
AU - Palmquist, Sarah M.
AU - Saleh, Mohammed M.
AU - Fellman, Bryan M.
AU - Fleming, Nicole D.
AU - Bhosale, Priya R.
AU - Sood, Anil K.
N1 - Funding Information:
This research was supported in part by the MD Anderson Ovarian Cancer Moon Shot; the National Institutes of Health through grants CA016672 (MD Anderson’s Cancer Center Support Grant), CA217685, CA101642, and CA209904; the American Cancer Society; the Ovarian Cancer Research Alliance; and the Frank McGraw Memorial Chair in Cancer Research. KFH is supported by a training fellowship from the Gulf Coast Consortia, through the Computational Cancer Biology Training Program (CPRIT Grant No. RP170593). Funding sources were not involved in study design, collection, analysis, or interpretation of data, writing the report, or decision to submit for publication.
Publisher Copyright:
© IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023
Y1 - 2023
N2 - Objective: A novel classification system of high-grade serous ovarian carcinoma based on gross morphology observed at pre-treatment laparoscopy was recently defined. The purpose of this study was to identify radiographic features unique to each morphologic subtype. Methods: This retrospective study included 109 patients with high-grade serous ovarian cancer who underwent pre-operative computed tomography (CT) scanning and laparoscopic assessment of disease burden between 1 April 2013 and 5 August 2015. Gross morphologic subtype had been previously assigned by laparoscopy. Two radiologists independently reviewed CT images for each patient, categorized disease at eight anatomic sites, and assessed for radiographic characteristics of interest: large infiltrative plaques, mass-like metastases, enhancing peritoneal lining, architectural distortion, fat stranding, calcifications, and lymph node involvement. Demographic and clinical information was summarized with descriptive statistics and compared using Student's t-tests, χ² tests, or Fisher exact tests as appropriate; kappa statistics were used to assess inter-reader agreement. Results: Certain radiographic features were found to be associated with gross morphologic subtype. Large infiltrative plaques were more common in type 1 disease (88.7% (47/53) vs 71.4% (25/35), p=0.04), while mass-like metastases were more often present in type 2 disease (48.6% (17/35) vs 22.6% (12/53), p=0.01). Additionally, radiographic presence of disease at the falciform ligament was more common in type 1 morphology (33.9% (19/56) vs 13.2% (5/38), p=0.02). Conclusion: Morphologic subtypes of high-grade serous ovarian cancer were associated with specific CT findings, including the presence of large infiltrative plaques, mass-like metastases, and falciform ligament involvement.
AB - Objective: A novel classification system of high-grade serous ovarian carcinoma based on gross morphology observed at pre-treatment laparoscopy was recently defined. The purpose of this study was to identify radiographic features unique to each morphologic subtype. Methods: This retrospective study included 109 patients with high-grade serous ovarian cancer who underwent pre-operative computed tomography (CT) scanning and laparoscopic assessment of disease burden between 1 April 2013 and 5 August 2015. Gross morphologic subtype had been previously assigned by laparoscopy. Two radiologists independently reviewed CT images for each patient, categorized disease at eight anatomic sites, and assessed for radiographic characteristics of interest: large infiltrative plaques, mass-like metastases, enhancing peritoneal lining, architectural distortion, fat stranding, calcifications, and lymph node involvement. Demographic and clinical information was summarized with descriptive statistics and compared using Student's t-tests, χ² tests, or Fisher exact tests as appropriate; kappa statistics were used to assess inter-reader agreement. Results: Certain radiographic features were found to be associated with gross morphologic subtype. Large infiltrative plaques were more common in type 1 disease (88.7% (47/53) vs 71.4% (25/35), p=0.04), while mass-like metastases were more often present in type 2 disease (48.6% (17/35) vs 22.6% (12/53), p=0.01). Additionally, radiographic presence of disease at the falciform ligament was more common in type 1 morphology (33.9% (19/56) vs 13.2% (5/38), p=0.02). Conclusion: Morphologic subtypes of high-grade serous ovarian cancer were associated with specific CT findings, including the presence of large infiltrative plaques, mass-like metastases, and falciform ligament involvement.
KW - Cystadenocarcinoma, Serous
KW - Ovarian Cancer
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U2 - 10.1136/ijgc-2022-004206
DO - 10.1136/ijgc-2022-004206
M3 - Article
C2 - 36948527
AN - SCOPUS:85152659801
SN - 1048-891X
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
M1 - ijgc-2022-004206
ER -