TY - JOUR
T1 - CheckMate 141
T2 - 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer
AU - Gillison, Maura L.
AU - Blumenschein, George
AU - Fayette, Jerome
AU - Guigay, Joel
AU - Colevas, A. Dimitrios
AU - Licitra, Lisa
AU - Harrington, Kevin J.
AU - Kasper, Stefan
AU - Vokes, Everett E.
AU - Even, Caroline
AU - Worden, Francis
AU - Saba, Nabil F.
AU - Iglesias Docampo, Lara Carmen
AU - Haddad, Robert
AU - Rordorf, Tamara
AU - Kiyota, Naomi
AU - Tahara, Makoto
AU - Monga, Manish
AU - Lynch, Mark
AU - Li, Li
AU - Ferris, Robert L.
N1 - Publisher Copyright:
© AlphaMed Press 2018
PY - 2018/9
Y1 - 2018/9
N2 - Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.
AB - Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.
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U2 - 10.1634/theoncologist.2017-0674
DO - 10.1634/theoncologist.2017-0674
M3 - Article
C2 - 29866947
AN - SCOPUS:85053050902
SN - 1083-7159
VL - 23
SP - 1079
EP - 1082
JO - Oncologist
JF - Oncologist
IS - 9
ER -