Chelator-based catheter lock solutions in eradicating organisms in biofilm

I. Raad, J. Rosenblatt, R. Reitzel, Y. Jiang, T. Dvorak, R. Hachem

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Two different chelator-based antimicrobial catheter lock solutions, methylene blue-citrate-parabens (MB-CIT) and minocycline-EDTA-25% ethanol (M-EDTA-25% ETOH), were compared in 2-h biofilm eradication experiments. Eradication of both mature and immature Gram-positive, Gram-negative, and fungal biofilms was assessed. M-EDTA-25% ETOH was able to fully eradicate all biofilms within 2 h. MB-CIT was only effective against immature biofilms but was unable to fully eradicate most of the mature biofilms tested.

Original languageEnglish (US)
Pages (from-to)586-588
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number1
DOIs
StatePublished - Jan 1 2013

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Biofilms
Chelating Agents
Catheters
Parabens
Edetic Acid
Methylene Blue
Citric Acid
Minocycline
Ethanol

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Chelator-based catheter lock solutions in eradicating organisms in biofilm. / Raad, I.; Rosenblatt, J.; Reitzel, R.; Jiang, Y.; Dvorak, T.; Hachem, R.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 1, 01.01.2013, p. 586-588.

Research output: Contribution to journalArticle

Raad, I. ; Rosenblatt, J. ; Reitzel, R. ; Jiang, Y. ; Dvorak, T. ; Hachem, R. / Chelator-based catheter lock solutions in eradicating organisms in biofilm. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 1. pp. 586-588.
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