TY - JOUR
T1 - Chelator-based catheter lock solutions in eradicating organisms in biofilm
AU - Raad, I.
AU - Rosenblatt, J.
AU - Reitzel, R.
AU - Jiang, Y.
AU - Dvorak, T.
AU - Hachem, R.
PY - 2013/1
Y1 - 2013/1
N2 - Two different chelator-based antimicrobial catheter lock solutions, methylene blue-citrate-parabens (MB-CIT) and minocycline-EDTA-25% ethanol (M-EDTA-25% ETOH), were compared in 2-h biofilm eradication experiments. Eradication of both mature and immature Gram-positive, Gram-negative, and fungal biofilms was assessed. M-EDTA-25% ETOH was able to fully eradicate all biofilms within 2 h. MB-CIT was only effective against immature biofilms but was unable to fully eradicate most of the mature biofilms tested.
AB - Two different chelator-based antimicrobial catheter lock solutions, methylene blue-citrate-parabens (MB-CIT) and minocycline-EDTA-25% ethanol (M-EDTA-25% ETOH), were compared in 2-h biofilm eradication experiments. Eradication of both mature and immature Gram-positive, Gram-negative, and fungal biofilms was assessed. M-EDTA-25% ETOH was able to fully eradicate all biofilms within 2 h. MB-CIT was only effective against immature biofilms but was unable to fully eradicate most of the mature biofilms tested.
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U2 - 10.1128/AAC.01287-12
DO - 10.1128/AAC.01287-12
M3 - Article
C2 - 23070163
AN - SCOPUS:84872049007
SN - 0066-4804
VL - 57
SP - 586
EP - 588
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 1
ER -