Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Y. Lee; N. M. Zacharias; D. Piwnica-Worms; P. K. Bhattacharya

doi:10.1039/c4cc06199c

Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Y. Lee, N. M. Zacharias, D. Piwnica-Worms, P. K. Bhattacharya

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-¹³C pyruvic acid.

Original language	English (US)
Pages (from-to)	13030-13033
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	86
DOIs	https://doi.org/10.1039/c4cc06199c
State	Published - Oct 2 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility

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10.1039/c4cc06199c

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Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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