Abstract
Activities of conventional antifungal agents, fludioxonil, strobilurin and antimycin A, which target the oxidative and osmotic stress response systems, were elevated by coapplication of certain benzo analogs (aldehydes and acids). Fungal tolerance to 2,3-dihydroxybenzaldehyde or 2,3-dihydroxybenzoic acid was found to rely upon mitochondrial superoxide dismutase (SOD2) or glutathione reductase (GLR1), genes regulated by the HOG1 signaling pathway, respectively. Thus, certain benzo analogs can be effective at targeting cellular oxidative stress response systems. The ability of these compounds to chemosensitize fungi for improved control with conventional antifungal agents is discussed.
Original language | English (US) |
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Pages (from-to) | 64-72 |
Number of pages | 9 |
Journal | FEMS Microbiology Letters |
Volume | 281 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2008 |
Keywords
- Aspergillus
- Filamentous fungi
- HOG1
- Oxidative stress response
- Saccharomyces cerevisiae
- Strobilurin
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics