Abstract
The pharmacology of the antiestrogen tamoxifen is reviewed. The drug is currently used extensively in the treatment of all stages of breast cancer and is being considered as a preventive agent for women at high risk for breast cancer. Extensive laboratory studies demonstrate that tamoxifen is a tumoristatic agent in models of mammary carcinogenesis. Any clinical applications must therefore consider long-term (5-10 years) treatment strategies. Tamoxifen prevents rat mammary carcinogenesis. However, the timing of the carcinogenic insult is unknown among women. Tamoxifen must be considered to be a chemosuppressive agent to prevent the appearance of the primary tumor rather than to prevent the initial carcinogenic insult.
Original language | English (US) |
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Pages (from-to) | 3-14 |
Number of pages | 12 |
Journal | Preventive Medicine |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Epidemiology
- Public Health, Environmental and Occupational Health