TY - JOUR
T1 - Chemotherapy for adenocarcinomas of bladder and urachal origin
T2 - 5-Fluorouracil, doxorubicin, and mitomycin-C
AU - Logothetis, Christopher J.
AU - Samuels, Melvin L.
AU - Ogden, Sheryl
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/9
Y1 - 1985/9
N2 - Eight patients with unresectable adenocarcinoma of the bladder or urachus were treated with chemotherapy. Four had received cisplatin-based chemotherapy (CISCA), all 4 failed to respond. All 8 received intravenous and/or intra-arterial 5 -fluorouracil, doxorubicin hydrochloride (Adriamycin), and mitomycin-C. Three of the 5 responding patients had short responses while 2 had achieved long-term control of disease. One is in complete remission for eleven plus months, and 1 patient had a partial remission of nineteen plus months. Five patients had serum CEA levels measured at presentation. In the 3 patients with an elevated CEA at presentation who responded to chemotherapy a corresponding drop in the initial level was seen. 5-Fluorouracil-based chemotherapy is effective in the management of adenocarcinoma of the bladder.
AB - Eight patients with unresectable adenocarcinoma of the bladder or urachus were treated with chemotherapy. Four had received cisplatin-based chemotherapy (CISCA), all 4 failed to respond. All 8 received intravenous and/or intra-arterial 5 -fluorouracil, doxorubicin hydrochloride (Adriamycin), and mitomycin-C. Three of the 5 responding patients had short responses while 2 had achieved long-term control of disease. One is in complete remission for eleven plus months, and 1 patient had a partial remission of nineteen plus months. Five patients had serum CEA levels measured at presentation. In the 3 patients with an elevated CEA at presentation who responded to chemotherapy a corresponding drop in the initial level was seen. 5-Fluorouracil-based chemotherapy is effective in the management of adenocarcinoma of the bladder.
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U2 - 10.1016/0090-4295(85)90121-9
DO - 10.1016/0090-4295(85)90121-9
M3 - Article
C2 - 3929441
AN - SCOPUS:0022239733
SN - 0090-4295
VL - 26
SP - 252
EP - 255
JO - Urology
JF - Urology
IS - 3
ER -