TY - JOUR
T1 - Chemotherapy for cervical carcinoma
T2 - Factors determining response and implications for clinical trial design
AU - Brader, Kevin R.
AU - Morris, Mitchell
AU - Levenback, Charles
AU - Levy, Lawrence
AU - Lucas, Kristin R.
AU - Gershenson, David M.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1998/5
Y1 - 1998/5
N2 - Purpose: To identify characteristics that predict response to chemotherapy in patients with advanced or recurrent squamous cell carcinoma of the cervix. Patients and Methods: Between January 1986 and May 1996, 190 chemotherapy-naive patients with advanced or recurrent squamous cell carcinoma of the cervix not amenable to curative radiation therapy or surgery were treated on 14 different chemotherapy protocols at M.D. Anderson Cancer Center. Patient's charts were retrospectively reviewed for patient demographics, tumor and treatment characteristics, and patterns of response and survival. Results: Of 190 patients, 22 had advanced or persistent disease and 168 had recurrent disease. Patients were treated with platinum-based (n = 95) and non-platinum-based (n = 95) regimens. The overall response rate was 20.0% (4.2% complete response; 15.8% partial response), with a median response duration of 4.8 months. Race, socioeconomic class, tumor stage and grade, mode of primary treatment, time from primary diagnosis to disease recurrence, initial performance status, and use of platinum-based therapy were not significant predictors of response. Age at time of chemotherapy (P = .001) and site of recurrence (P = .044) were significant determinants by multivariate analysis. Patients who were older were more likely to respond to therapy, and the response rate for patients in whom disease recurred outside the irradiated field was 25.2%, compared with a 5.3% response rate for patients with recurrent disease limited to a previously irradiated field. Conclusion: The site of disease recurrence and patient age should be token into account when designing chemotherapy trials and also when considering chemotherapy in the patient with recurrent cervix cancer.
AB - Purpose: To identify characteristics that predict response to chemotherapy in patients with advanced or recurrent squamous cell carcinoma of the cervix. Patients and Methods: Between January 1986 and May 1996, 190 chemotherapy-naive patients with advanced or recurrent squamous cell carcinoma of the cervix not amenable to curative radiation therapy or surgery were treated on 14 different chemotherapy protocols at M.D. Anderson Cancer Center. Patient's charts were retrospectively reviewed for patient demographics, tumor and treatment characteristics, and patterns of response and survival. Results: Of 190 patients, 22 had advanced or persistent disease and 168 had recurrent disease. Patients were treated with platinum-based (n = 95) and non-platinum-based (n = 95) regimens. The overall response rate was 20.0% (4.2% complete response; 15.8% partial response), with a median response duration of 4.8 months. Race, socioeconomic class, tumor stage and grade, mode of primary treatment, time from primary diagnosis to disease recurrence, initial performance status, and use of platinum-based therapy were not significant predictors of response. Age at time of chemotherapy (P = .001) and site of recurrence (P = .044) were significant determinants by multivariate analysis. Patients who were older were more likely to respond to therapy, and the response rate for patients in whom disease recurred outside the irradiated field was 25.2%, compared with a 5.3% response rate for patients with recurrent disease limited to a previously irradiated field. Conclusion: The site of disease recurrence and patient age should be token into account when designing chemotherapy trials and also when considering chemotherapy in the patient with recurrent cervix cancer.
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U2 - 10.1200/JCO.1998.16.5.1879
DO - 10.1200/JCO.1998.16.5.1879
M3 - Article
C2 - 9586904
AN - SCOPUS:0031804714
SN - 0732-183X
VL - 16
SP - 1879
EP - 1884
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 5
ER -