Chemotherapy-related cognitive impairment in older patients with cancer

Kah Poh Loh; Michelle C. Janelsins; Supriya G. Mohile; Holly M. Holmes; Tina Hsu; Sharon K. Inouye; Meghan S. Karuturi; Gretchen G. Kimmick; Stuart M. Lichtman; Allison Magnuson; Mary I. Whitehead; Melisa L. Wong; Tim A. Ahles

doi:10.1016/j.jgo.2016.04.008

Chemotherapy-related cognitive impairment in older patients with cancer

Kah Poh Loh, Michelle C. Janelsins, Supriya G. Mohile, Holly M. Holmes, Tina Hsu, Sharon K. Inouye, Meghan S. Karuturi, Gretchen G. Kimmick, Stuart M. Lichtman, Allison Magnuson, Mary I. Whitehead, Melisa L. Wong, Tim A. Ahles

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.

Original language	English (US)
Pages (from-to)	270-280
Number of pages	11
Journal	Journal of Geriatric Oncology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/j.jgo.2016.04.008
State	Published - Jul 1 2016

Keywords

Cancer treatment
Chemotherapy
Cognitive impairment
Older patients
Research gaps

ASJC Scopus subject areas

Oncology
Geriatrics and Gerontology

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10.1016/j.jgo.2016.04.008

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title = "Chemotherapy-related cognitive impairment in older patients with cancer",

abstract = "Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.",

keywords = "Cancer treatment, Chemotherapy, Cognitive impairment, Older patients, Research gaps",

author = "Loh, {Kah Poh} and Janelsins, {Michelle C.} and Mohile, {Supriya G.} and Holmes, {Holly M.} and Tina Hsu and Inouye, {Sharon K.} and Karuturi, {Meghan S.} and Kimmick, {Gretchen G.} and Lichtman, {Stuart M.} and Allison Magnuson and Whitehead, {Mary I.} and Wong, {Melisa L.} and Ahles, {Tim A.}",

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year = "2016",

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doi = "10.1016/j.jgo.2016.04.008",

language = "English (US)",

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T1 - Chemotherapy-related cognitive impairment in older patients with cancer

AU - Loh, Kah Poh

AU - Janelsins, Michelle C.

AU - Mohile, Supriya G.

AU - Holmes, Holly M.

AU - Hsu, Tina

AU - Inouye, Sharon K.

AU - Karuturi, Meghan S.

AU - Kimmick, Gretchen G.

AU - Lichtman, Stuart M.

AU - Magnuson, Allison

AU - Whitehead, Mary I.

AU - Wong, Melisa L.

AU - Ahles, Tim A.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.

AB - Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.

KW - Cancer treatment

KW - Chemotherapy

KW - Cognitive impairment

KW - Older patients

KW - Research gaps

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Chemotherapy-related cognitive impairment in older patients with cancer

Abstract

Keywords

ASJC Scopus subject areas

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