TY - JOUR
T1 - Chest radiographic and CT manifestations of chronic granulomatous disease in adults
AU - Godoy, Myrna C.B.
AU - Vos, Patrick M.
AU - Cooperberg, Peter L.
AU - Lydell, Carmen P.
AU - Phillips, Peter
AU - Müller, Nestor L.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/11
Y1 - 2008/11
N2 - OBJECTIVE. The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults. MATERIALS AND METHODS. We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection. RESULTS. Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation. CONCLUSION. The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.
AB - OBJECTIVE. The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults. MATERIALS AND METHODS. We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection. RESULTS. Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation. CONCLUSION. The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.
KW - Chest imaging
KW - Chronic granulomatous disease
KW - Primary immunodeficiency disorders
KW - Pulmonary imaging
KW - Pulmonary infection
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U2 - 10.2214/AJR.07.3482
DO - 10.2214/AJR.07.3482
M3 - Article
C2 - 18941103
AN - SCOPUS:55549123001
SN - 0361-803X
VL - 191
SP - 1570
EP - 1575
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 5
ER -