Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge

Fouad El Dana; Sofia Alexandra Garces Narvaez; Nader K. El-Mallawany; Jennifer E. Agrusa; Zo Ann E. Dreyer; Andrea N. Marcogliese; Mohamed Tarek Elghetany; Jyotinder N. Punia; Chi Young Ok; Keyur P. Patel; Dolores H. Lopez-Terrada; Kevin E. Fisher; Choladda V. Curry

doi:10.1177/10935266241230600

Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge

Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K. El-Mallawany, Jennifer E. Agrusa, Zo Ann E. Dreyer, Andrea N. Marcogliese, Mohamed Tarek Elghetany, Jyotinder N. Punia, Chi Young Ok, Keyur P. Patel, Dolores H. Lopez-Terrada, Kevin E. Fisher, Choladda V. Curry

Hematopathology

Research output: Contribution to journal › Article › peer-review

Abstract

We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as “DLBCL-NOS with MYC rearrangement” using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).

Original language	English (US)
Journal	Pediatric and Developmental Pathology
DOIs	https://doi.org/10.1177/10935266241230600
State	Accepted/In press - 2024

Keywords

aggressive b-cell non-Hodgkin lymphoma
B-NHL
BCL2
Burkitt
DLBCL
ICC
pediatric
WHO-HAEM5

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.1177/10935266241230600

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El Dana, F., Garces Narvaez, S. A., El-Mallawany, N. K., Agrusa, J. E., Dreyer, Z. A. E., Marcogliese, A. N., Elghetany, M. T., Punia, J. N., Ok, C. Y., Patel, K. P., Lopez-Terrada, D. H., Fisher, K. E., & Curry, C. V. (Accepted/In press). Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge. Pediatric and Developmental Pathology. https://doi.org/10.1177/10935266241230600

Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge. / El Dana, Fouad; Garces Narvaez, Sofia Alexandra; El-Mallawany, Nader K. et al.
In: Pediatric and Developmental Pathology, 2024.

Research output: Contribution to journal › Article › peer-review

El Dana, F, Garces Narvaez, SA, El-Mallawany, NK, Agrusa, JE, Dreyer, ZAE, Marcogliese, AN, Elghetany, MT, Punia, JN, Ok, CY , Patel, KP, Lopez-Terrada, DH, Fisher, KE & Curry, CV 2024, 'Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge', Pediatric and Developmental Pathology. https://doi.org/10.1177/10935266241230600

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title = "Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge",

abstract = "We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as “DLBCL-NOS with MYC rearrangement” using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).",

keywords = "aggressive b-cell non-Hodgkin lymphoma, B-NHL, BCL2, Burkitt, DLBCL, ICC, pediatric, WHO-HAEM5",

author = "{El Dana}, Fouad and {Garces Narvaez}, {Sofia Alexandra} and El-Mallawany, {Nader K.} and Agrusa, {Jennifer E.} and Dreyer, {Zo Ann E.} and Marcogliese, {Andrea N.} and Elghetany, {Mohamed Tarek} and Punia, {Jyotinder N.} and Ok, {Chi Young} and Patel, {Keyur P.} and Lopez-Terrada, {Dolores H.} and Fisher, {Kevin E.} and Curry, {Choladda V.}",

year = "2024",

doi = "10.1177/10935266241230600",

language = "English (US)",

journal = "Pediatric and Developmental Pathology",

issn = "1093-5266",

publisher = "Society for Pediatric Pathology",

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T1 - Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma

T2 - A Diagnostic Challenge

AU - El Dana, Fouad

AU - Garces Narvaez, Sofia Alexandra

AU - El-Mallawany, Nader K.

AU - Agrusa, Jennifer E.

AU - Dreyer, Zo Ann E.

AU - Marcogliese, Andrea N.

AU - Elghetany, Mohamed Tarek

AU - Punia, Jyotinder N.

AU - Ok, Chi Young

AU - Patel, Keyur P.

AU - Lopez-Terrada, Dolores H.

AU - Fisher, Kevin E.

AU - Curry, Choladda V.

PY - 2024

Y1 - 2024

N2 - We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as “DLBCL-NOS with MYC rearrangement” using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).

AB - We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as “DLBCL-NOS with MYC rearrangement” using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA).

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KW - BCL2

KW - Burkitt

KW - DLBCL

KW - ICC

KW - pediatric

KW - WHO-HAEM5

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ER -

Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge

Abstract

Keywords

ASJC Scopus subject areas

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