TY - JOUR
T1 - Childhood lymphomatoid papulosis Type D, a rare and challenging diagnosis
AU - Brown, Danielle N.
AU - Blessing, Melissa M.
AU - Marcogliese, Andrea N.
AU - Vega, Francisco
AU - Prose, Neil
AU - Metry, Denise
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - A 10-year-old female with a several-year history of pityriasis lichenoides (PL) presented with a new, asymptomatic, large, and necrotic ulcer of her right upper arm. Skin biopsy was consistent with lymphomatoid papulosis (LyP) Type D, a recently recognized subtype of LyP that is distinguished histologically by marked epidermotropism and a perivascular infiltrate of medium-sized pleomorphic lymphocytes with a cytotoxic phenotype (CD3+, CD8+). This is only the sixth reported case of LyP Type D in a child, and while the prognosis in children appears favorable, with no reports of progression to lymphoma to date, more experience in children with longer-term follow-up is needed. Our case highlights both the challenging clinical diagnosis, since in our patient the longstanding clinical presentation was indistinguishable from PL, as well as histopathologic diagnosis, which required expert opinion and consensus.
AB - A 10-year-old female with a several-year history of pityriasis lichenoides (PL) presented with a new, asymptomatic, large, and necrotic ulcer of her right upper arm. Skin biopsy was consistent with lymphomatoid papulosis (LyP) Type D, a recently recognized subtype of LyP that is distinguished histologically by marked epidermotropism and a perivascular infiltrate of medium-sized pleomorphic lymphocytes with a cytotoxic phenotype (CD3+, CD8+). This is only the sixth reported case of LyP Type D in a child, and while the prognosis in children appears favorable, with no reports of progression to lymphoma to date, more experience in children with longer-term follow-up is needed. Our case highlights both the challenging clinical diagnosis, since in our patient the longstanding clinical presentation was indistinguishable from PL, as well as histopathologic diagnosis, which required expert opinion and consensus.
KW - lymphomatoid papulosis
KW - pediatric dermatology
UR - http://www.scopus.com/inward/record.url?scp=85133648775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133648775&partnerID=8YFLogxK
U2 - 10.1111/pde.15076
DO - 10.1111/pde.15076
M3 - Article
C2 - 35817594
AN - SCOPUS:85133648775
SN - 0736-8046
VL - 39
SP - 943
EP - 945
JO - Pediatric Dermatology
JF - Pediatric Dermatology
IS - 6
ER -