Abstract
Primary sclerosing cholangitis and colitis are known predisposing factors for bile duct cancer, but their exact pro-oncogenic mechanisms are unclear. In this issue of Cancer Discovery, Zhang and colleagues identify intestinal barrier impairment as a key mechanism, resulting in gut microbes spilling into the portal vein, in turn recruiting immunosuppressive myeloid-derived suppressor cells and promoting cholangiocarcinoma.
Original language | English (US) |
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Pages (from-to) | 1014-1015 |
Number of pages | 2 |
Journal | Cancer discovery |
Volume | 11 |
Issue number | 5 |
DOIs | |
State | Published - May 2021 |
ASJC Scopus subject areas
- Oncology