Chromatid breakage: Cytosine arabinoside-induced lesions inhibited by ultraviolet irradiation

William F. Benedict; Myron Karon

doi:10.1126/science.171.3972.680

Chromatid breakage: Cytosine arabinoside-induced lesions inhibited by ultraviolet irradiation

William F. Benedict, Myron Karon

Genitourinary Medical Oncology

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6 Scopus citations

Abstract

Exposure to ultraviolet light can reduce the frequency of chromatid breaks induced by cytosine arabinoside in the DNA synthetic and post-DNA synthetic phases of the cell cycle. This effect can be correlated temporally with a decrease in the uptake of tritiated thymidine after ultraviolet treatment, implying that the genesis of such breakage is intimately related to DNA synthesis and that such synthesis is not confined to the DNA synthetic phase.

Original language	English (US)
Pages (from-to)	680-682
Number of pages	3
Journal	Science
Volume	171
Issue number	3972
DOIs	https://doi.org/10.1126/science.171.3972.680
State	Published - 1971

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title = "Chromatid breakage: Cytosine arabinoside-induced lesions inhibited by ultraviolet irradiation",

abstract = "Exposure to ultraviolet light can reduce the frequency of chromatid breaks induced by cytosine arabinoside in the DNA synthetic and post-DNA synthetic phases of the cell cycle. This effect can be correlated temporally with a decrease in the uptake of tritiated thymidine after ultraviolet treatment, implying that the genesis of such breakage is intimately related to DNA synthesis and that such synthesis is not confined to the DNA synthetic phase.",

author = "Benedict, {William F.} and Myron Karon",

year = "1971",

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AU - Karon, Myron

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N2 - Exposure to ultraviolet light can reduce the frequency of chromatid breaks induced by cytosine arabinoside in the DNA synthetic and post-DNA synthetic phases of the cell cycle. This effect can be correlated temporally with a decrease in the uptake of tritiated thymidine after ultraviolet treatment, implying that the genesis of such breakage is intimately related to DNA synthesis and that such synthesis is not confined to the DNA synthetic phase.

AB - Exposure to ultraviolet light can reduce the frequency of chromatid breaks induced by cytosine arabinoside in the DNA synthetic and post-DNA synthetic phases of the cell cycle. This effect can be correlated temporally with a decrease in the uptake of tritiated thymidine after ultraviolet treatment, implying that the genesis of such breakage is intimately related to DNA synthesis and that such synthesis is not confined to the DNA synthetic phase.

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Chromatid breakage: Cytosine arabinoside-induced lesions inhibited by ultraviolet irradiation

Abstract

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