TY - JOUR
T1 - Chromatin challenges during DNA replication
T2 - A systems representation
AU - Kohn, Kurt W.
AU - Aladjem, Mirit I.
AU - Weinstein, John N.
AU - Pommier, Yves
PY - 2008/1
Y1 - 2008/1
N2 - In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.
AB - In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.
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U2 - 10.1091/mbc.E07-06-0528
DO - 10.1091/mbc.E07-06-0528
M3 - Review article
C2 - 17959828
AN - SCOPUS:38749084852
SN - 1059-1524
VL - 19
SP - 1
EP - 7
JO - Molecular Biology of the Cell
JF - Molecular Biology of the Cell
IS - 1
ER -