Chromophobe Renal Cell Carcinoma With Sarcomatoid Transformation

Neil A. Abrahams; Alberto G. Ayala; Bogdan Czerniak

doi:10.1016/S1092-9134(03)00072-8

Chromophobe Renal Cell Carcinoma With Sarcomatoid Transformation

Neil A. Abrahams, Alberto G. Ayala, Bogdan Czerniak

Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.

Original language	English (US)
Pages (from-to)	296-299
Number of pages	4
Journal	Annals of Diagnostic Pathology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/S1092-9134(03)00072-8
State	Published - Oct 2003

Keywords

Arcomatoid carcinoma
Chromophobe carcinoma
Kidney morphology

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S1092-9134(03)00072-8

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title = "Chromophobe Renal Cell Carcinoma With Sarcomatoid Transformation",

abstract = "We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.",

keywords = "Arcomatoid carcinoma, Chromophobe carcinoma, Kidney morphology",

author = "Abrahams, {Neil A.} and Ayala, {Alberto G.} and Bogdan Czerniak",

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AU - Abrahams, Neil A.

AU - Ayala, Alberto G.

AU - Czerniak, Bogdan

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N2 - We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.

AB - We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.

KW - Arcomatoid carcinoma

KW - Chromophobe carcinoma

KW - Kidney morphology

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Chromophobe Renal Cell Carcinoma With Sarcomatoid Transformation

Abstract

Keywords

ASJC Scopus subject areas

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