Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

Bhanu Rajput; Angus Marshall; Ann M. Killary; Peter A. Lalley; Susan L. Naylor; Dominique Belin; Richard J. Rickles; Sidney Strickland

doi:10.1007/BF01534500

Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

Bhanu Rajput, Angus Marshall, Ann M. Killary, Peter A. Lalley, Susan L. Naylor, Dominique Belin, Richard J. Rickles, Sidney Strickland

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.

Original language	English (US)
Pages (from-to)	581-586
Number of pages	6
Journal	Somatic Cell and Molecular Genetics
Volume	13
Issue number	5
DOIs	https://doi.org/10.1007/BF01534500
State	Published - Sep 1987
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse",

abstract = "The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.",

author = "Bhanu Rajput and Angus Marshall and Killary, {Ann M.} and Lalley, {Peter A.} and Naylor, {Susan L.} and Dominique Belin and Rickles, {Richard J.} and Sidney Strickland",

year = "1987",

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doi = "10.1007/BF01534500",

language = "English (US)",

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journal = "Somatic Cell and Molecular Genetics",

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T1 - Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

AU - Rajput, Bhanu

AU - Marshall, Angus

AU - Killary, Ann M.

AU - Lalley, Peter A.

AU - Naylor, Susan L.

AU - Belin, Dominique

AU - Rickles, Richard J.

AU - Strickland, Sidney

PY - 1987/9

Y1 - 1987/9

N2 - The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.

AB - The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.

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Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

Abstract

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