@article{2805ad7bf8b9455b96fda89085be0e41,
title = "Chromosomal instability in tumor initiation and development",
abstract = "Chromosomal instability (CIN) is one of the major forms of CIN is stable between precursor lesions, primary tumor, and genomic instability in various human cancers and is recognized metastases or if it evolves during these steps. In this review, we as a common hallmark of tumorigenesis and heterogeneity. describe the influence of CIN on the various steps in tumor However, some malignant tumors show a paucity of chromo-initiation and development. Given the recognized significant somal alterations, suggesting that tumor progression and evo-effects of CIN in cancer, CIN-targeted therapeutics could have a lution can occur in the absence of CIN. It is unclear whether major impact on improving clinical outcomes.",
author = "Bach, {Duc Hiep} and Wei Zhang and Sood, {Anil K.}",
note = "Funding Information: This work was supported, in whole or in part, by NIH grants (P50CA217685, P50 CA098258, UH3TR000943, R35 CA209904, and CA016672), the Frank McGraw Memorial Chair in Cancer Research, and the American Cancer Society Research Professor Award, the Blanton-Davis Ovarian Cancer Research Program to A.K. Sood, a fellowship from the National Foundation for Cancer Research, a Hanes and Wills Family endowed professorship in cancer at the Wake Forest Baptist Comprehensive Cancer Center, the Cancer Center Support Grant from the NCI to the Comprehensive Cancer Center of Wake Forest Baptist Medical Center (P30 CA012197) to W. Zhang. The authors thank Tamara K. Locke from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for editorial assistance. Publisher Copyright: {\textcopyright} 2019 American Association for Cancer Research.",
year = "2019",
month = aug,
day = "15",
doi = "10.1158/0008-5472.CAN-18-3235",
language = "English (US)",
volume = "79",
pages = "3995--4002",
journal = "Cancer Research",
issn = "0008-5472",
number = "16",
}