TY - JOUR
T1 - Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277
AU - Liang, Hong
AU - Guo, Wei
AU - Nagarajan, Lalitha
N1 - Funding Information:
The authors gratefully acknowledge support from the National Institutes of Health, CA 55164, and Core Grant CA16672 to M. D. Anderson Cancer Center. We thank Kathy Tucker for assistance with preparation of the manuscript and members of our laboratory for critically reading the manuscript.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - A novel C2H2 zinc finger gene, ZNF277, has been localized to human chromosome 7q31.1. The gene is encoded by 12 exons in a genomic fragment of >100 kb between the microsatellite markers D7S523 and D7S471, deleted in a number of malignancies. The predicted open reading frame (ORF) of 438 amino acids shows an overall homology of 50% to the putative ORF F46B6.7 of Caenorhabditis elegans. The presence of a 30-amino-acid coiled-coil domain in both the C. elegans ORF F46B6.7 and ZNF277 is suggestive of functional similarities. ESTs for the murine orthologue ZFP277 are found in early embryonic stem cells, 16-cell stage embryo, and blastocysts. The evolutionary conservation and the expression profile suggest ZNF277 to be a critical regulator of development and differentiation. (C) 2000 Academic Press.
AB - A novel C2H2 zinc finger gene, ZNF277, has been localized to human chromosome 7q31.1. The gene is encoded by 12 exons in a genomic fragment of >100 kb between the microsatellite markers D7S523 and D7S471, deleted in a number of malignancies. The predicted open reading frame (ORF) of 438 amino acids shows an overall homology of 50% to the putative ORF F46B6.7 of Caenorhabditis elegans. The presence of a 30-amino-acid coiled-coil domain in both the C. elegans ORF F46B6.7 and ZNF277 is suggestive of functional similarities. ESTs for the murine orthologue ZFP277 are found in early embryonic stem cells, 16-cell stage embryo, and blastocysts. The evolutionary conservation and the expression profile suggest ZNF277 to be a critical regulator of development and differentiation. (C) 2000 Academic Press.
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U2 - 10.1006/geno.2000.6198
DO - 10.1006/geno.2000.6198
M3 - Article
C2 - 10860669
AN - SCOPUS:0034210286
SN - 0888-7543
VL - 66
SP - 226
EP - 228
JO - Genomics
JF - Genomics
IS - 2
ER -