Chromosomal rearrangements and microRNAs: A new cancer link with clinical implications

George A. Calin; Carlo M. Croce

doi:10.1172/JCI32577

Chromosomal rearrangements and microRNAs: A new cancer link with clinical implications

George A. Calin, Carlo M. Croce

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

Original language	English (US)
Pages (from-to)	2059-2066
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	117
Issue number	8
DOIs	https://doi.org/10.1172/JCI32577
State	Published - Aug 1 2007

ASJC Scopus subject areas

General Medicine

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title = "Chromosomal rearrangements and microRNAs: A new cancer link with clinical implications",

abstract = "There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.",

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AB - There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

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Chromosomal rearrangements and microRNAs: A new cancer link with clinical implications

Abstract

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