TY - JOUR
T1 - Chromosomal translocation t(14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin's lymphoma and chronic lymphocytic leukemia
T2 - A molecular genetic analysis of 176 cases
AU - Van Krieken, Johan H.J.M.
AU - McKeithan, Timothy W.
AU - Raghoebier, Sourish
AU - Medeiros, L. Jeffrey
AU - Kluin, Philip M.
AU - Raffeld, Mark
PY - 1990/12
Y1 - 1990/12
N2 - Using a probe for the newly described bcl-3 gene near the breakpoint of the t(14;19), 176 cases of non-Hodgkin lymphoma and B cell chronic lymphocytic leukemia were analyzed. Rearrangement of the bcl-3 gene was found in only one case; a follicular lymphoma involving the salivary gland that had progressed to a diffuse large cell lymphoma. We conclude that rearrangement of the bcl-3 gene as detected by our method occurs rarely in mature B or T cell neoplasms.
AB - Using a probe for the newly described bcl-3 gene near the breakpoint of the t(14;19), 176 cases of non-Hodgkin lymphoma and B cell chronic lymphocytic leukemia were analyzed. Rearrangement of the bcl-3 gene was found in only one case; a follicular lymphoma involving the salivary gland that had progressed to a diffuse large cell lymphoma. We conclude that rearrangement of the bcl-3 gene as detected by our method occurs rarely in mature B or T cell neoplasms.
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M3 - Article
C2 - 2243504
AN - SCOPUS:0025607279
SN - 0887-6924
VL - 4
SP - 811
EP - 812
JO - Leukemia
JF - Leukemia
IS - 12
ER -