Abstract
THE REFINEMENT of cytogenetic techniques has enabled the identification of chromosomal abnormalities commonly associated with specific types of malignancies. Reciprocal chromosomal translocations are the most frequently detected cytogenetic abnormality in leukemias and lymphomas, and the application of molecular biologic techniques has enabled the genes associated with these chromosomal breakpoints to be identified and characterized. These studies have led to the discovery of new oncogenes and have provided valuable information on the genetic basis of transformation and tumor progression. Insights gained from these studies are being considered in the development of new treatment strategies on behalf of cancer patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 264-273 |
| Number of pages | 10 |
| Journal | Cancer Bulletin |
| Volume | 46 |
| Issue number | 3 |
| State | Published - 1994 |
ASJC Scopus subject areas
- Cancer Research