TY - JOUR
T1 - Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors
AU - Wang, Ling Mei
AU - Killary, Ann M.
AU - Fang, Xiao En
AU - Parriott, Sandi K.
AU - Lalley, Peter A.
AU - Bell, Graeme I.
AU - Sakaguchi, Alan Y.
N1 - Funding Information:
We thank David Russell for the human LDLR probe, James Buchanan and Rick George for help with the photography, Diana Hottle and Linda Howell for help with the manuscript, and Anne Georgulas for technical assistance. This work was supported by Public Health Service Grant CA39186 from the National Cancer Institute, by Program Project Grant AGO6872 from the National Institute of Aging, and by Grant AHA 86-G-367 from the Texas Affiliate of the American Heart Association (A.M.K.).
PY - 1988/8
Y1 - 1988/8
N2 - Receptors for insulin, low-density lipoprotein, and colony stimulating factor 1 are associated with diabetes, atherosclerosis, and cancer in man. Complementary DNA clones for Insr, Ldlr, and Csfmr were used to chromosomally assign the three genes in mouse. In contrast to their close linkage on the short arm of human Chromosome 19, Insr and Ldlr are asyntenic, residing on mouse Chromosomes 8 and 9, respectively. The genes for CSF1R, CSF1, CSF2, IL-3, and IL-5 form a cluster on the long arm of human Chromosome 5. In mouse, Csfm, Csfgm, and IL-3 are syntenic on Chromosome 11. The Csfmr gene was assigned to mouse Chromosome 18 and is thus unlinked to other members of this gene cluster. These gene assignments provide additional topographical information on conservation of linkage groups in man and mouse and provide a genetic framework for evaluating the possible roles for the three receptor genes in genetic diseases in mouse.
AB - Receptors for insulin, low-density lipoprotein, and colony stimulating factor 1 are associated with diabetes, atherosclerosis, and cancer in man. Complementary DNA clones for Insr, Ldlr, and Csfmr were used to chromosomally assign the three genes in mouse. In contrast to their close linkage on the short arm of human Chromosome 19, Insr and Ldlr are asyntenic, residing on mouse Chromosomes 8 and 9, respectively. The genes for CSF1R, CSF1, CSF2, IL-3, and IL-5 form a cluster on the long arm of human Chromosome 5. In mouse, Csfm, Csfgm, and IL-3 are syntenic on Chromosome 11. The Csfmr gene was assigned to mouse Chromosome 18 and is thus unlinked to other members of this gene cluster. These gene assignments provide additional topographical information on conservation of linkage groups in man and mouse and provide a genetic framework for evaluating the possible roles for the three receptor genes in genetic diseases in mouse.
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U2 - 10.1016/0888-7543(88)90150-4
DO - 10.1016/0888-7543(88)90150-4
M3 - Article
C2 - 3066742
AN - SCOPUS:0024062851
SN - 0888-7543
VL - 3
SP - 172
EP - 175
JO - Genomics
JF - Genomics
IS - 2
ER -