Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease

Sara S. Strom; G. U. Yun; Alice J. Sigurdson; Nell M. Bailey; Christopher I. Amos; Margaret R. Spitz; Maria A. Rodriguez; Jan C. Liang

doi:10.3109/10428199809058364

Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease

Sara S. Strom, G. U. Yun, Alice J. Sigurdson, Nell M. Bailey, Christopher I. Amos, Margaret R. Spitz, Maria A. Rodriguez, Jan C. Liang

Epidemiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR) = 11.3, p = 0.02) and age (RR = 1.08, p = 0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.

Original language	English (US)
Pages (from-to)	561-566
Number of pages	6
Journal	Leukemia and Lymphoma
Volume	28
Issue number	5-6
DOIs	https://doi.org/10.3109/10428199809058364
State	Published - 1998

Keywords

Chromosome breaks
Hodgkin's disease
Second cancers
Sister chromatid exchange

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.3109/10428199809058364

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@article{4b452fc4ba384651ba1c9f2e99ee02ad,

title = "Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease",

abstract = "Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR) = 11.3, p = 0.02) and age (RR = 1.08, p = 0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.",

keywords = "Chromosome breaks, Hodgkin's disease, Second cancers, Sister chromatid exchange",

author = "Strom, {Sara S.} and Yun, {G. U.} and Sigurdson, {Alice J.} and Bailey, {Nell M.} and Amos, {Christopher I.} and Spitz, {Margaret R.} and Rodriguez, {Maria A.} and Liang, {Jan C.}",

note = "Funding Information: We thank the patients for their collaboration, the physicians for their support, and Grace Tee for data collection. This project was supported in part by National Institutes of Health grants K07-CA63 183 (SSS), R03-CA64121 (SSS), and R01-CA54358 (JCL) from the National Cancer Institute.",

year = "1998",

doi = "10.3109/10428199809058364",

language = "English (US)",

volume = "28",

pages = "561--566",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "5-6",

}

TY - JOUR

T1 - Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease

AU - Strom, Sara S.

AU - Yun, G. U.

AU - Sigurdson, Alice J.

AU - Bailey, Nell M.

AU - Amos, Christopher I.

AU - Spitz, Margaret R.

AU - Rodriguez, Maria A.

AU - Liang, Jan C.

N1 - Funding Information: We thank the patients for their collaboration, the physicians for their support, and Grace Tee for data collection. This project was supported in part by National Institutes of Health grants K07-CA63 183 (SSS), R03-CA64121 (SSS), and R01-CA54358 (JCL) from the National Cancer Institute.

PY - 1998

Y1 - 1998

N2 - Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR) = 11.3, p = 0.02) and age (RR = 1.08, p = 0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.

AB - Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR) = 11.3, p = 0.02) and age (RR = 1.08, p = 0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.

KW - Chromosome breaks

KW - Hodgkin's disease

KW - Second cancers

KW - Sister chromatid exchange

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Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease

Abstract

Keywords

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