Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm

Guilin Tang; Lesley J. Woods; Sa A. Wang; Doreen Brettler; Mary Andersen; Patricia M. Miron; Liberto Pechet; Bruce A. Woda; Suyang Hao

doi:10.1016/j.humpath.2009.02.011

Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm

Guilin Tang, Lesley J. Woods, Sa A. Wang, Doreen Brettler, Mary Andersen, Patricia M. Miron, Liberto Pechet, Bruce A. Woda, Suyang Hao

Hematopathology

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17 Scopus citations

Abstract

Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.

Original language	English (US)
Pages (from-to)	1194-1199
Number of pages	6
Journal	Human Pathology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.humpath.2009.02.011
State	Published - Aug 2009

Keywords

Chronic basophilic leukemia
Cytogenetics
Immunophenotype
Myeloproliferative neoplasm

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2009.02.011

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title = "Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm",

abstract = "Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.",

keywords = "Chronic basophilic leukemia, Cytogenetics, Immunophenotype, Myeloproliferative neoplasm",

author = "Guilin Tang and Woods, {Lesley J.} and Wang, {Sa A.} and Doreen Brettler and Mary Andersen and Miron, {Patricia M.} and Liberto Pechet and Woda, {Bruce A.} and Suyang Hao",

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doi = "10.1016/j.humpath.2009.02.011",

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T2 - a rare form of chronic myeloproliferative neoplasm

AU - Tang, Guilin

AU - Woods, Lesley J.

AU - Wang, Sa A.

AU - Brettler, Doreen

AU - Andersen, Mary

AU - Miron, Patricia M.

AU - Pechet, Liberto

AU - Woda, Bruce A.

AU - Hao, Suyang

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AB - Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.

KW - Chronic basophilic leukemia

KW - Cytogenetics

KW - Immunophenotype

KW - Myeloproliferative neoplasm

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Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm

Abstract

Keywords

ASJC Scopus subject areas

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