TY - JOUR
T1 - Chronic Granulocytic Leukemia with Respiratory Distress
T2 - Efficacy of Emergency Leukapheresis
AU - Karp, Daniel D.
AU - Beck, J. Robert
AU - Cornell, Cornelius J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1981/9
Y1 - 1981/9
N2 - In the absence of preexisting pulmonary disease, progressive respiratory failure caused by leukostasis associated with uncontrolled chronic granulocytic leukemia developed in two patients. The conditions of both patients improved dramatically with aggressive leukapheresis. Clinical improvement correlated with decreased pulmonary wedge pressure, while vascular volume remained constant. Continuous-flow cell separation removed numerous immature myeloid cells, replaced them with oxygen-carrying erythrocytes, and maintained a constant blood volume. The course of these two patients demonstrates the use of continuous-flow leukapheresis in an intensive care unit to reduce leukocyte count and manifestations of leukostasis rapidly, while improving the oxygen-carrying capacity of blood, without exposing the patients to dangerously large shifts in fluid volume.
AB - In the absence of preexisting pulmonary disease, progressive respiratory failure caused by leukostasis associated with uncontrolled chronic granulocytic leukemia developed in two patients. The conditions of both patients improved dramatically with aggressive leukapheresis. Clinical improvement correlated with decreased pulmonary wedge pressure, while vascular volume remained constant. Continuous-flow cell separation removed numerous immature myeloid cells, replaced them with oxygen-carrying erythrocytes, and maintained a constant blood volume. The course of these two patients demonstrates the use of continuous-flow leukapheresis in an intensive care unit to reduce leukocyte count and manifestations of leukostasis rapidly, while improving the oxygen-carrying capacity of blood, without exposing the patients to dangerously large shifts in fluid volume.
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U2 - 10.1001/archinte.1981.00340100109024
DO - 10.1001/archinte.1981.00340100109024
M3 - Article
C2 - 6943985
AN - SCOPUS:0019391505
SN - 0003-9926
VL - 141
SP - 1353
EP - 1354
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 10
ER -