Abstract
To assess the role of sex dependent brain vasopressinergic transmission in the modulation of the neural effects of interleukin-1, castrated male rats that are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini device containing 10 μg AVP whereas intact male rats were implanted with a similar device containing 50 Mg of dPTyr(Me)AVP, a specific antagonist of the vasopressor-like receptors of vasopressin. Control rats in each sex group were implanted with an Accurel device containing distilled water. Acute intracerebroventricular injection of 1.25-2.50 ng recombinant human interleukin-1β decreased in a dose and time-dependent manner social investigation of a juvenile conspecific. This effect was more intense in intact rats chronically infused with dPTyr(Me)AVP and less intense in castrates infused with AVP. These results confirm the modulatory role of sex-dependent vasopressinergic neurotransmission on the neural effects of interleukin-1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 897-900 |
| Number of pages | 4 |
| Journal | Brain Research Bulletin |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1992 |
| Externally published | Yes |
Keywords
- Behavior
- Castration
- Interleukin-1
- Male rat
- Vasopressin
ASJC Scopus subject areas
- General Neuroscience