Abstract
Our understanding of chronic myelomonocytic leukemia (CMML) has evolved tremendously over the past decade. Large-scale sequencing studies have led to increased insight into the genomic landscape of CMML and clinical implications of these changes. This in turn has resulted in refined and improved risk stratification models, which to date remain versatile and subject to remodeling, as new and evolving studies continue to refine our understanding of this disease. In this article, we present an up-todate review of CMML from a hematopathology perspective, while providing a clinically practical summary that sheds light on the constant evolution of our understanding of this disease.
Original language | English (US) |
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Pages (from-to) | 142-149 |
Number of pages | 8 |
Journal | Journal of Immunotherapy and Precision Oncology |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
Keywords
- ASXL1
- CMML
- Chronic myelomonocytic leukemia
- MDS
- MPN
- Monocyte
- Myelodysplastic
- Myelproliferative
- NRAS
- SRSF2
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Immunology
- Immunology and Allergy