Chronic nausea and anorexia in advanced cancer patients: A possible role for autonomic dysfunction

Eduardo Bruera, Zolly Catz, Richard Hooper, Brian Lentle, Neil MacDonald

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Five patients with advanced cancer who complained of unexplained chronic (more than fourweeks) nausea and anorexia, underwent a gastric emptying scan and clinical and electrocardiographic tests for the detection of autonomic failure. Sixteen of 23 tests were abnormal in the patients, v 0 of 25 in five healthy adult controls (p<0.001). Mean gastric emptying time was 190±83 minutes in patients v 65±6 minutes in the control group (p<0.001). We conclude that at least in some cases, patients with advanced cancer who complain of chronic nausea and anorexia may suffer a dysfunction of the autonomic nervous system manifested by delayed gastric emptying and abnormal cardiovascular autonomic tests. J Pain Sympt Manag 1987;2:19–21.

Original languageEnglish (US)
Pages (from-to)19-21
Number of pages3
JournalJournal of pain and symptom management
Volume2
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Chronic nausea
  • advanced
  • anorexia
  • autonomic dysfunction
  • blood pressure
  • cancer
  • changes
  • electrocardiogram changes
  • gastric emptying time
  • nuclear medicine investigation
  • postural
  • symptoms

ASJC Scopus subject areas

  • General Nursing
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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