TY - JOUR
T1 - Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
AU - Safaeian, Mahboobeh
AU - Gao, Yu Tang
AU - Sakoda, Lori C.
AU - Quraishi, Sabah M.
AU - Rashid, Asif
AU - Wang, Bing Shen
AU - Chen, Jinbo
AU - Pruckler, James
AU - Mintz, Eric
AU - Hsing, Ann W.
N1 - Funding Information:
We thank Jie Deng, Jiarong Cheng, Lu Sun, Kai Wu, and the staff at the Shanghai Cancer Institute for data collection, specimen collection, and processing, surgeons at the collaborating hospitals for data collection, and local pathologists for pathology review; Shelley Niwa of Westat for data preparation and management; and Janis Koci of the Scientific Applications International Corporation for management of the biological samples. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the reviews or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
PY - 2011
Y1 - 2011
N2 - Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, biliary stone cases without evidence of cancer, and healthy subjects in a large population-based case-control study in Shanghai, China. Participants included 627 newly diagnosed primary biliary tract cancer patients; 1,037 biliary stone cases (774 gallbladder and 263 bile-duct) and 959 healthy subjects without a history of cancer, randomly selected from the Shanghai Resident Registry. Overall only 6/2,293 (0.26%) were Typhi positive. The prevalence of Typhi was 1/457 (0.22%), 4/977 (0.41%), and 1/859 (0.12%) among cancer cases, biliary-stone cases, and population controls, respectively. We did not find an association between Typhi and biliary cancer in Shanghai, due to the very low prevalence of chronic carriers in this population. The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population.
AB - Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, biliary stone cases without evidence of cancer, and healthy subjects in a large population-based case-control study in Shanghai, China. Participants included 627 newly diagnosed primary biliary tract cancer patients; 1,037 biliary stone cases (774 gallbladder and 263 bile-duct) and 959 healthy subjects without a history of cancer, randomly selected from the Shanghai Resident Registry. Overall only 6/2,293 (0.26%) were Typhi positive. The prevalence of Typhi was 1/457 (0.22%), 4/977 (0.41%), and 1/859 (0.12%) among cancer cases, biliary-stone cases, and population controls, respectively. We did not find an association between Typhi and biliary cancer in Shanghai, due to the very low prevalence of chronic carriers in this population. The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population.
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U2 - 10.1186/1750-9378-6-6
DO - 10.1186/1750-9378-6-6
M3 - Article
C2 - 21535882
AN - SCOPUS:79955393850
SN - 1750-9378
VL - 6
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
IS - 1
M1 - 6
ER -