TY - JOUR
T1 - Circadian rhythm of plasma renin activity in older normal and essential hypertensive men
T2 - Relation with inactive renin, aldosterone, cortisol and REM sleep
AU - Stern, Naftali
AU - Sowers, James R.
AU - McGinty, Dennis
AU - Beahm, Elizabeth
AU - Littner, Michael
AU - Catania, Robert
AU - Eggena, Peter
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1986/10
Y1 - 1986/10
N2 - The 24-h pattern of plasma renin activity (PRA), inactive renin (IR), plasma aldosterone (PA) and Cortisol was studied in 13 normal men and 12 male patients with essential hypertension, all of whom were older than 55 years. Following gradual habituation over 4 days to the sleep laboratory and intravenous lines, blood samples were obtained every 2 h between 0900-2100 h and every 30 min between 2100-0900 h, during which sleep was also monitored. Plasma renin activity showed a circadian rhythm in both groups, but mean levels were lower in the hypertensive subjects (0.92 ± 0.03 versus 1.41 ± 0.06 ng/ml per h). The circadian rhythm of PRA in older men appeared to follow the same pattern described in younger individuals. Rapid eye movement (REM) sleep was associated with a small decrease in PRA, but this link was only evident in the normotensive group. Mean 24-h IR levels were also lower in the hypertensive group (7.26 ±0.18 versus 15.10 + 0.47 ng/ml per h) but were not affected by clock-time and generally showed no association with the 24-h PRA cycle. Mean 24-h PA was closely related to cortisol but not to PRA in both groups. Mean PA levels of the two groups were similar. Thus, the PA:PRA ratio was higher in the hypertensive group. The higher basal PA:PRA ratio in older hypertensives that emerged over the 24-h study period may reflect increased sensitivity of the adrenal gland to angiotensin II (ANG II) in hypertension of the elderly.
AB - The 24-h pattern of plasma renin activity (PRA), inactive renin (IR), plasma aldosterone (PA) and Cortisol was studied in 13 normal men and 12 male patients with essential hypertension, all of whom were older than 55 years. Following gradual habituation over 4 days to the sleep laboratory and intravenous lines, blood samples were obtained every 2 h between 0900-2100 h and every 30 min between 2100-0900 h, during which sleep was also monitored. Plasma renin activity showed a circadian rhythm in both groups, but mean levels were lower in the hypertensive subjects (0.92 ± 0.03 versus 1.41 ± 0.06 ng/ml per h). The circadian rhythm of PRA in older men appeared to follow the same pattern described in younger individuals. Rapid eye movement (REM) sleep was associated with a small decrease in PRA, but this link was only evident in the normotensive group. Mean 24-h IR levels were also lower in the hypertensive group (7.26 ±0.18 versus 15.10 + 0.47 ng/ml per h) but were not affected by clock-time and generally showed no association with the 24-h PRA cycle. Mean 24-h PA was closely related to cortisol but not to PRA in both groups. Mean PA levels of the two groups were similar. Thus, the PA:PRA ratio was higher in the hypertensive group. The higher basal PA:PRA ratio in older hypertensives that emerged over the 24-h study period may reflect increased sensitivity of the adrenal gland to angiotensin II (ANG II) in hypertension of the elderly.
KW - Essential hypertension
KW - Inactive renin
KW - Plasma aldosterone
KW - Plasma renin activity
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U2 - 10.1097/00004872-198610000-00005
DO - 10.1097/00004872-198610000-00005
M3 - Article
C2 - 3540117
AN - SCOPUS:0023005793
SN - 0263-6352
VL - 4
SP - 543
EP - 550
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 5
ER -