TY - JOUR
T1 - Circulating E-selectin and tumor necrosis factor-α in extraarticular involvement and joint disease activity in rheumatoid arthritis
AU - Corona-Sanchez, Esther G.
AU - Gonzalez-Lopez, Laura
AU - Muñoz-Valle, Jose F.
AU - Vazquez-Del Mercado, Monica
AU - Lopez-Olivo, Maria A.
AU - Aguilar-Chavez, Erika A.
AU - Salazar-Paramo, Mario
AU - Loaiza-Cardenas, Carlos
AU - Oregon-Romero, Edith
AU - Navarro-Hernandez, Rosa E.
AU - Gamez-Nava, Jorge I.
N1 - Funding Information:
Acknowledgments Funding for this project was provided by a grant from the Fondo de Fomento a la Investigación Instituto Mexicano del Seguro Social (IMSS) number: IMSS-2004/034 and 2005/1/I/048.
PY - 2009/1
Y1 - 2009/1
N2 - In this cross-sectional study, we assessed the relationship between circulating TNF-α and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-α than non-ExRA (32 ± 9 vs. 28 ± 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-α had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage.
AB - In this cross-sectional study, we assessed the relationship between circulating TNF-α and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-α than non-ExRA (32 ± 9 vs. 28 ± 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P = <0.001). Circulating TNF-α had no correlation with sE-selectin or disease activity. We concluded that sE-selectin correlated with severity of joint disease, further follow-up studies should evaluate if sE-selectin is useful as prognosis marker for progression of articular damage.
KW - Articular activity
KW - Extraarticular involvement
KW - Rheumatoid arthritis
KW - TNF-α
KW - sE-selectin
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U2 - 10.1007/s00296-008-0688-3
DO - 10.1007/s00296-008-0688-3
M3 - Article
C2 - 18726101
AN - SCOPUS:57649228999
SN - 0172-8172
VL - 29
SP - 281
EP - 286
JO - Rheumatology International
JF - Rheumatology International
IS - 3
ER -