Abstract
Background: Circulating tumor cells (CTCs) are associated with inferior prognosis in metastatic breast cancer (MBC). We hypothesized that the relationship between CTCs and disease subtype would provide a better understanding of the clinical and biologic behavior of MBC. Patients and methods: We retrospectively analyzed 517 MBC patients treated at a single institution. Subtypes of primary tumors were analyzed by immunohistochemical (IHC) or fluorescent in situ hybridization analyses and CTCs were enumerated by CellSearch ® at starting a new therapy. Overall survival (OS) and progression-free survival durations for each IHC subtype were determined. Results: At a median follow-up of 24.6 months, 276 of 517 (53%) patients had died. The median OS for patients with <5 and ≥5 CTCs were 32.4 and 18.3 months, respectively (P < 0.001). Except in HER2+ patients, the prognostic value of CTCs was independent of disease subtype and disease site. Conclusions: In this large retrospective study, CTCs were strongly predictive of survival in all MBC subtypes except HER2+ patients who had been treated with targeted therapy. Our results clearly demonstrate the value of enumerating CTCs in MBC and strongly suggest an interesting biological implication in the HER2+ subset of patients that need to be further explored.
Original language | English (US) |
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Pages (from-to) | 1144-1150 |
Number of pages | 7 |
Journal | Annals of Oncology |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - May 2012 |
Keywords
- Circulating tumor cells
- HER2
- Immunohistochemical subtypes
- Metastatic breast cancer
- Tumor markers
ASJC Scopus subject areas
- Hematology
- Oncology