TY - JOUR
T1 - Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection
AU - Takahashi, Koichi
AU - Yabe, Mariko
AU - Shapira, Ilan
AU - Pierce, Sherry
AU - Garcia-Manero, Guillermo
AU - Varma, Mala
PY - 2012/11
Y1 - 2012/11
N2 - We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p=0.019), had more complex cytogenetics (p=0.015), and more often had 7q deletion or monosomy 7 (p=0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p=0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.
AB - We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p=0.019), had more complex cytogenetics (p=0.015), and more often had 7q deletion or monosomy 7 (p=0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p=0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.
KW - Cytogenetics
KW - Human immunodeficiency virus
KW - Myelodysplastic syndrome
UR - http://www.scopus.com/inward/record.url?scp=84866307799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866307799&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2012.08.003
DO - 10.1016/j.leukres.2012.08.003
M3 - Article
C2 - 22917767
AN - SCOPUS:84866307799
SN - 0145-2126
VL - 36
SP - 1376
EP - 1379
JO - Leukemia Research
JF - Leukemia Research
IS - 11
ER -