TY - JOUR
T1 - Clinical applicability of proposed algorithm for identifying individuals at risk for hereditary hematologic malignancies
AU - Clifford, Maggie
AU - Bannon, Sarah
AU - Bednar, Erica M.
AU - Czerwinski, Jennifer
AU - Davis, Jessica
AU - Dunnington, Leslie
AU - Shahrukh Hashmi, S.
AU - DiNardo, Courtney D.
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/10/15
Y1 - 2019/10/15
N2 - Multiple genes have been identified to cause hereditary predispositions to hematologic malignancies, and characterized by an increased risk to develop myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and/or aplastic anemia (AA). Referral algorithms for patients who may be at higher risk have been proposed, with limited data regarding applicability. Our study aimed to evaluate referral criteria on a population of MDS/AML/AA patients. Demographic information and medical history were obtained from 608 patients referred over a 9-month period. Median age at diagnosis was 67 years (56–73), 387 (64%) were male, and the majority of individuals (54.9%) had AML. Overall, 406 individuals (66.8%) had insufficient documentation to determine whether certain criteria were met. Two hundred and two (33.2%) individuals met at least one criteria for genetic counseling referral; however, only nine (4.5%) were referred. Increased documentation of personal and family history is necessary to better assess and validate the applicability of these criteria.
AB - Multiple genes have been identified to cause hereditary predispositions to hematologic malignancies, and characterized by an increased risk to develop myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and/or aplastic anemia (AA). Referral algorithms for patients who may be at higher risk have been proposed, with limited data regarding applicability. Our study aimed to evaluate referral criteria on a population of MDS/AML/AA patients. Demographic information and medical history were obtained from 608 patients referred over a 9-month period. Median age at diagnosis was 67 years (56–73), 387 (64%) were male, and the majority of individuals (54.9%) had AML. Overall, 406 individuals (66.8%) had insufficient documentation to determine whether certain criteria were met. Two hundred and two (33.2%) individuals met at least one criteria for genetic counseling referral; however, only nine (4.5%) were referred. Increased documentation of personal and family history is necessary to better assess and validate the applicability of these criteria.
KW - Hereditary hematologic malignancies
KW - cancer genetics risk assessment
KW - clinical detection algorithm
KW - identifying at risk individuals
KW - leukemia
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U2 - 10.1080/10428194.2019.1630618
DO - 10.1080/10428194.2019.1630618
M3 - Article
C2 - 31274040
AN - SCOPUS:85068540299
SN - 1042-8194
VL - 60
SP - 3020
EP - 3027
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 12
ER -