Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes

Indu Varier; Brieze R. Keeley; Rosemarie Krupar; Alexis Patsias; Joanna Dong; Nikita Gupta; Arjun K. Parasher; Eric M. Genden; Brett A. Miles; Marita Teng; Richard L. Bakst; Vishal Gupta; Krzysztof J. Misiukiewicz; Elizabeth Y. Chiao; Michael E. Scheurer; Simon Laban; David Zhang; Fei Ye; Miao Cui; Elizabeth G. Demicco; Marshall R. Posner; Andrew G. Sikora

doi:10.1002/hed.24442

Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes

Indu Varier, Brieze R. Keeley, Rosemarie Krupar, Alexis Patsias, Joanna Dong, Nikita Gupta, Arjun K. Parasher, Eric M. Genden, Brett A. Miles, Marita Teng, Richard L. Bakst, Vishal Gupta, Krzysztof J. Misiukiewicz, Elizabeth Y. Chiao, Michael E. Scheurer, Simon Laban, David Zhang, Fei Ye, Miao Cui, Elizabeth G. DemiccoMarshall R. Posner, Andrew G. Sikora

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. Methods: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. Results: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p =.021) and higher clinical T classification (p =.008) compared to HPV16 OPC, but there was no significant survival difference. Conclusion: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.

Original language	English (US)
Pages (from-to)	1330-1337
Number of pages	8
Journal	Head and Neck
Volume	38
Issue number	9
DOIs	https://doi.org/10.1002/hed.24442
State	Published - Sep 2016
Externally published	Yes

Keywords

genotypes
head and neck squamous cell carcinoma
human papillomavirus (HPV)
oropharyngeal cancer

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/hed.24442

Cite this

Varier, I., Keeley, B. R., Krupar, R., Patsias, A., Dong, J., Gupta, N., Parasher, A. K., Genden, E. M., Miles, B. A., Teng, M., Bakst, R. L., Gupta, V., Misiukiewicz, K. J., Chiao, E. Y., Scheurer, M. E., Laban, S., Zhang, D., Ye, F., Cui, M., ... Sikora, A. G. (2016). Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes. Head and Neck, 38(9), 1330-1337. https://doi.org/10.1002/hed.24442

Varier, I, Keeley, BR, Krupar, R, Patsias, A, Dong, J, Gupta, N, Parasher, AK, Genden, EM, Miles, BA, Teng, M, Bakst, RL, Gupta, V, Misiukiewicz, KJ, Chiao, EY, Scheurer, ME, Laban, S, Zhang, D, Ye, F, Cui, M, Demicco, EG, Posner, MR & Sikora, AG 2016, 'Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes', Head and Neck, vol. 38, no. 9, pp. 1330-1337. https://doi.org/10.1002/hed.24442

@article{e43d6937bfe342aa963b240dfe44f4bc,

title = "Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes",

abstract = "Background: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. Methods: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. Results: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p =.021) and higher clinical T classification (p =.008) compared to HPV16 OPC, but there was no significant survival difference. Conclusion: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.",

keywords = "genotypes, head and neck squamous cell carcinoma, human papillomavirus (HPV), oropharyngeal cancer",

author = "Indu Varier and Keeley, {Brieze R.} and Rosemarie Krupar and Alexis Patsias and Joanna Dong and Nikita Gupta and Parasher, {Arjun K.} and Genden, {Eric M.} and Miles, {Brett A.} and Marita Teng and Bakst, {Richard L.} and Vishal Gupta and Misiukiewicz, {Krzysztof J.} and Chiao, {Elizabeth Y.} and Scheurer, {Michael E.} and Simon Laban and David Zhang and Fei Ye and Miao Cui and Demicco, {Elizabeth G.} and Posner, {Marshall R.} and Sikora, {Andrew G.}",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = sep,

doi = "10.1002/hed.24442",

language = "English (US)",

volume = "38",

pages = "1330--1337",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "9",

}

TY - JOUR

T1 - Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes

AU - Varier, Indu

AU - Keeley, Brieze R.

AU - Krupar, Rosemarie

AU - Patsias, Alexis

AU - Dong, Joanna

AU - Gupta, Nikita

AU - Parasher, Arjun K.

AU - Genden, Eric M.

AU - Miles, Brett A.

AU - Teng, Marita

AU - Bakst, Richard L.

AU - Gupta, Vishal

AU - Misiukiewicz, Krzysztof J.

AU - Chiao, Elizabeth Y.

AU - Scheurer, Michael E.

AU - Laban, Simon

AU - Zhang, David

AU - Ye, Fei

AU - Cui, Miao

AU - Demicco, Elizabeth G.

AU - Posner, Marshall R.

AU - Sikora, Andrew G.

PY - 2016/9

Y1 - 2016/9

N2 - Background: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. Methods: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. Results: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p =.021) and higher clinical T classification (p =.008) compared to HPV16 OPC, but there was no significant survival difference. Conclusion: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.

AB - Background: The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. Methods: This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain reaction (PCR). Baseline data and outcomes were compared between HPV16 and high-risk non-HPV16 groups. Results: High-risk non-HPV16 genotypes accounted for 9% of HPV-related OPC. Of the 27 total high-risk non-HPV16 OPCs, HPV35 was most prevalent (48%). High-risk non-HPV16 OPC presented at a slightly higher age (p =.021) and higher clinical T classification (p =.008) compared to HPV16 OPC, but there was no significant survival difference. Conclusion: Clinical characteristics of high-risk non-HPV16 OPC were largely consistent with those of HPV16 OPC. Additional multi-institutional studies will be required to demonstrate conclusively that the favorable prognosis of patients with HPV16 applies to all high-risk HPV types.

KW - genotypes

KW - head and neck squamous cell carcinoma

KW - human papillomavirus (HPV)

KW - oropharyngeal cancer

UR - http://www.scopus.com/inward/record.url?scp=84987837059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987837059&partnerID=8YFLogxK

U2 - 10.1002/hed.24442

DO - 10.1002/hed.24442

M3 - Article

C2 - 27080140

AN - SCOPUS:84987837059

SN - 1043-3074

VL - 38

SP - 1330

EP - 1337

JO - Head and Neck

JF - Head and Neck

IS - 9

ER -

Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this