TY - JOUR
T1 - Clinical controversies
T2 - Proton therapy for thoracic tumors
AU - De Ruysscher, Dirk
AU - Chang, Joe Y.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/4
Y1 - 2013/4
N2 - Photon and proton therapy techniques have both improved dramatically over the past decade. As a result, high radiation doses can be delivered while sparing organs at risk. However, in many series, older proton techniques have been compared with contemporary photon techniques, hampering a fair comparison. By virtue of their physical properties and because of modern 4-dimensional and imaging evolution, protons show theoretical superiority compared with photons. Current nonrandomized studies suggest that protons may indeed spare organs at risk much better that the best available photon techniques, leading to fewer side effects and the possibility for safe dose escalation. This is the basis for ongoing randomized trials.
AB - Photon and proton therapy techniques have both improved dramatically over the past decade. As a result, high radiation doses can be delivered while sparing organs at risk. However, in many series, older proton techniques have been compared with contemporary photon techniques, hampering a fair comparison. By virtue of their physical properties and because of modern 4-dimensional and imaging evolution, protons show theoretical superiority compared with photons. Current nonrandomized studies suggest that protons may indeed spare organs at risk much better that the best available photon techniques, leading to fewer side effects and the possibility for safe dose escalation. This is the basis for ongoing randomized trials.
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U2 - 10.1016/j.semradonc.2012.11.010
DO - 10.1016/j.semradonc.2012.11.010
M3 - Article
C2 - 23473688
AN - SCOPUS:84875256779
SN - 1053-4296
VL - 23
SP - 115
EP - 119
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 2
ER -