Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning

Derek MacFadden; Bei Bei Zhang; Kristy K. Brock; Mojgan Hodaie; Normand Laperriere; Michael Schwartz; May Tsao; Jeffrey Stainsby; Gina Lockwood; David Mikulis; Cynthia Ménard

doi:10.1016/j.ijrobp.2009.03.020

Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning

Derek MacFadden, Bei Bei Zhang, Kristy K. Brock, Mojgan Hodaie, Normand Laperriere, Michael Schwartz, May Tsao, Jeffrey Stainsby, Gina Lockwood, David Mikulis, Cynthia Ménard

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Purpose: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. Methods and Materials: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. Results: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for 3T, p > .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). Conclusion: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used. Crown

Original language	English (US)
Pages (from-to)	1472-1479
Number of pages	8
Journal	International Journal of Radiation Oncology Biology Physics
Volume	76
Issue number	5
DOIs	https://doi.org/10.1016/j.ijrobp.2009.03.020
State	Published - Apr 2010
Externally published	Yes

Keywords

Gamma knife
geometric accuracy
image-guidance
magnetic resonance imaging
radiosurgery

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2009.03.020

Cite this

MacFadden, D., Zhang, B. B., Brock, K. K., Hodaie, M., Laperriere, N., Schwartz, M., Tsao, M., Stainsby, J., Lockwood, G., Mikulis, D., & Ménard, C. (2010). Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning. International Journal of Radiation Oncology Biology Physics, 76(5), 1472-1479. https://doi.org/10.1016/j.ijrobp.2009.03.020

MacFadden, D, Zhang, BB, Brock, KK, Hodaie, M, Laperriere, N, Schwartz, M, Tsao, M, Stainsby, J, Lockwood, G, Mikulis, D & Ménard, C 2010, 'Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning', International Journal of Radiation Oncology Biology Physics, vol. 76, no. 5, pp. 1472-1479. https://doi.org/10.1016/j.ijrobp.2009.03.020

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abstract = "Purpose: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. Methods and Materials: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. Results: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for 3T, p > .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). Conclusion: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used. Crown",

keywords = "Gamma knife, geometric accuracy, image-guidance, magnetic resonance imaging, radiosurgery",

author = "Derek MacFadden and Zhang, {Bei Bei} and Brock, {Kristy K.} and Mojgan Hodaie and Normand Laperriere and Michael Schwartz and May Tsao and Jeffrey Stainsby and Gina Lockwood and David Mikulis and Cynthia M{\'e}nard",

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doi = "10.1016/j.ijrobp.2009.03.020",

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AU - MacFadden, Derek

AU - Zhang, Bei Bei

AU - Brock, Kristy K.

AU - Hodaie, Mojgan

AU - Laperriere, Normand

AU - Schwartz, Michael

AU - Tsao, May

AU - Stainsby, Jeffrey

AU - Lockwood, Gina

AU - Mikulis, David

AU - Ménard, Cynthia

PY - 2010/4

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N2 - Purpose: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. Methods and Materials: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. Results: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for 3T, p > .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). Conclusion: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used. Crown

AB - Purpose: Increasing the magnetic resonance imaging (MRI) field strength can improve image resolution and quality, but concerns remain regarding the influence on geometric fidelity. The objectives of the present study were to spatially investigate the effect of 3-Tesla (3T) MRI on clinical target localization for stereotactic radiosurgery. Methods and Materials: A total of 39 patients were enrolled in a research ethics board-approved prospective clinical trial. Imaging (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively analyzed in a representative cohort of patients with tumor (n = 4) and functional (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target volumes was determined by the mean discrepancy between the average gross target volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement from an averaged surface and volume congruency. Spatial congruency and the reproducibility of functional radiosurgical targets was determined by comparing the mean and standard deviation of the isocenter coordinates. Results: Overall, the mean absolute discrepancy across all patients was 0.67 mm (95% confidence interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for 3T, p > .4), and the gross target volume surface mean displacements were similar within and between users. The overall average isocenter coordinate discrepancy for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval, 0.20-0.48), with no patient-specific differences between the mean values (p >.2) or standard deviations (p >.1). Conclusion: Our results have provided clinically relevant evidence supporting the spatial validity of 3T MRI for use in stereotactic radiosurgery under the imaging conditions used. Crown

KW - Gamma knife

KW - geometric accuracy

KW - image-guidance

KW - magnetic resonance imaging

KW - radiosurgery

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Clinical Evaluation of Stereotactic Target Localization Using 3-Tesla MRI for Radiosurgery Planning

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